Storm in a coffee cup: caffeine modifies brain activation to social signals of threat.
Storm in a coffee cup: caffeine modifies brain activation to social signals of threat.
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咖啡杯中的风暴：咖啡因会改变大脑对威胁社交信号的激活。
DOI：
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发表时间：
2012
影响因子：
4.2
通讯作者：
P. Rogers
中科院分区：
文献类型：
--
作者：
J. E. Smith;A. Lawrence;A. Diukova;R. Wise;P. Rogers
咖啡因是一种腺苷A β和A（2A）受体拮抗剂，是世界上最流行的精神兴奋剂药物，但它也具有焦虑性。咖啡因引起的焦虑的神经相关性目前尚不清楚。这项研究调查了咖啡因对涉及社会威胁处理和焦虑的大脑区域的影响。参与者是14名健康男性非/不频繁的咖啡因消费者。在双盲安慰剂对照交叉设计中，他们接受了血氧水平依赖性功能性磁共振成像（fMRI），同时在两次fMRI会议中接受咖啡因（250 mg）或安慰剂后1小时进行情绪面部处理任务（平衡，1周洗脱期）。在治疗前和治疗后2小时，他们评估了焦虑和精神警觉性，并测量了血压。结果表明，咖啡因诱导了威胁相关（愤怒/恐惧表情>快乐表情）中脑导水管周围灰质激活，并消除了威胁相关的内侧前额叶皮层壁激活。咖啡因对威胁相关杏仁核激活程度的影响与膳食咖啡因摄入水平呈负相关。与这些与威胁相关的大脑激活的变化同时，咖啡因增加了自评焦虑和舒张压。咖啡因不影响初级视觉皮层的激活。这些结果首次证明了咖啡因的焦虑作用的潜在神经相关性，并且它们暗示杏仁核是咖啡因耐受性的关键部位。
Caffeine, an adenosine A₁ and A(2A) receptor antagonist, is the most popular psychostimulant drug in the world, but it is also anxiogenic. The neural correlates of caffeine-induced anxiety are currently unknown. This study investigated the effects of caffeine on brain regions implicated in social threat processing and anxiety. Participants were 14 healthy male non/infrequent caffeine consumers. In a double-blind placebo-controlled crossover design, they underwent blood oxygenation level-dependent functional magnetic resonance imaging (fMRI) while performing an emotional face processing task 1 h after receiving caffeine (250 mg) or placebo in two fMRI sessions (counterbalanced, 1-week washout). They rated anxiety and mental alertness, and their blood pressure was measured, before and 2 h after treatment. Results showed that caffeine induced threat-related (angry/fearful faces > happy faces) midbrain-periaqueductal gray activation and abolished threat-related medial prefrontal cortex wall activation. Effects of caffeine on extent of threat-related amygdala activation correlated negatively with level of dietary caffeine intake. In concurrence with these changes in threat-related brain activation, caffeine increased self-rated anxiety and diastolic blood pressure. Caffeine did not affect primary visual cortex activation. These results are the first to demonstrate potential neural correlates of the anxiogenic effect of caffeine, and they implicate the amygdala as a key site for caffeine tolerance.
影响因子：
2.5
作者：
Gothard, K. M.;Battaglia, F. P.;Amaral, D. G.
通讯作者：
Amaral, D. G.
影响因子：
21.1
作者：
B. Fredholm;K. Bättig;J. Holmén;A. Nehlig;E. Zvartau
通讯作者：
B. Fredholm;K. Bättig;J. Holmén;A. Nehlig;E. Zvartau
影响因子：
10.3
作者：
Tuescher, Oliver;Protopopescu, Xenia;Pan, Hong;Cloitre, Marylene;Butler, Tracy;Goldstein, Martin;Root, James C.;Engelien, Almut;Furman, Daniella;Silverman, Michael;Yang, Yihong;Gorman, Jack;LeDoux, Joseph;Silbersweig, David;Stern, Emily
通讯作者：
Stern, Emily