Differential activity of subgenual cingulate and brainstem in panic disorder and PTSD.
Differential activity of subgenual cingulate and brainstem in panic disorder and PTSD.
复制标题
DOI：
10.1016/j.janxdis.2010.09.010
复制
发表时间：
2011-03
影响因子：
10.3
通讯作者：
Stern, Emily
中科院分区：
文献类型：
--
作者：
Tuescher, Oliver;Protopopescu, Xenia;Pan, Hong;Cloitre, Marylene;Butler, Tracy;Goldstein, Martin;Root, James C.;Engelien, Almut;Furman, Daniella;Silverman, Michael;Yang, Yihong;Gorman, Jack;LeDoux, Joseph;Silbersweig, David;Stern, Emily
关键词：
大多数惊恐障碍（PD）的功能性神经影像学研究都集中在静息状态，并探讨了PD与健康对照的关系，而不是与其他焦虑症的关系。在这里，PD患者，创伤后应激障碍（PTSD）患者，和健康对照组进行了研究与功能磁共振成像利用指示恐惧条件反射范式，将威胁和安全条件。相对于创伤后应激障碍和对照组，PD患者表现出显着减少激活的威胁条件和增加活动的安全条件下，在膝下扣带，腹侧纹状体和扩展杏仁核，以及中脑导水管周围灰质，这表明异常反应，在这个关键区域的恐惧表达。PTSD受试者没有表现出在对照组中发现的活动减少的时间模式。
Most functional neuroimaging studies of panic disorder (PD) have focused on the resting state, and have explored PD in relation to healthy controls rather than in relation to other anxiety disorders. Here, PD patients, Posttraumatic stress disorder (PTSD) patients, and healthy control subjects were studied with functional magnetic resonance imaging utilizing an instructed fear conditioning paradigm incorporating both Threat and Safe conditions. Relative to PTSD and control subjects, PD patients demonstrated significantly less activation to the Threat condition and increased activity to the Safe condition in the subgenual cingulate, ventral striatum and extended amygdala, as well as in midbrain periaquaeductal grey, suggesting abnormal reactivity in this key region for fear expression. PTSD subjects failed to show the temporal pattern of activity decrease found in control subjects.
登录
查看更多内容
影响因子：
4.1
作者：
Lissek S;Rabin SJ;McDowell DJ;Dvir S;Bradford DE;Geraci M;Pine DS;Grillon C
通讯作者：
Grillon C
影响因子：
5.7
作者：
Gu, H;Feng, HH;Yang, YH
通讯作者：
Yang, YH
影响因子：
10.6
作者：
Protopopescu, X;Pan, H;Stern, E
通讯作者：
Stern, E
影响因子：
7.4
作者：
Sheikh, JI;Woodward, SH;Leskin, GA
通讯作者：
Leskin, GA
DOI：
10.1111/j.1749-6632.1999.tb09278.x
发表时间：
1999-01-01
期刊：
ADVANCING FROM THE VENTRAL STRIATUM TO THE EXTENDED AMYGDALA
影响因子：
--
作者：
Price, JL
通讯作者：
Price, JL