Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death.
Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death.
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DOI：
10.3390/molecules28104085
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发表时间：
2023-05-14
期刊：
影响因子：
--
通讯作者：
Matsuda Y
中科院分区：
文献类型：
--
作者：
Fujii J;Soma Y;Matsuda Y
向基态三重态分子氧的能量转移导致产生单线态分子氧（1O2），其具有强氧化能力。光，特别是紫外线A，对光敏分子的照射导致1O2的产生，1O2被认为在引起皮肤损伤和老化中起作用。还应该注意的是，1O2是在光动力疗法（PDT）过程中产生的主要杀肿瘤成分。虽然II型光动力作用不仅产生1O2，还产生其他反应性物质，但内过氧化物在温和暴露于热时释放纯1O2，因此被认为是用于研究目的的有益化合物。关于目标分子，1O2优先与不饱和脂肪酸反应，产生脂质过氧化。在催化中心含有活性半胱氨酸基团的酶易受1O2暴露的影响。核酸中的鸟嘌呤碱基也容易受到氧化修饰，并且携带具有氧化鸟嘌呤单元的DNA的细胞可能经历突变。由于1O2除了光动力学反应之外还在各种生理反应中产生，克服与其检测和用于其产生的方法相关的技术挑战将使其在生物系统中的潜在功能得到更好的理解。
Energy transfer to ground state triplet molecular oxygen results in the generation of singlet molecular oxygen (1O2), which has potent oxidizing ability. Irradiation of light, notably ultraviolet A, to a photosensitizing molecule results in the generation of 1O2, which is thought to play a role in causing skin damage and aging. It should also be noted that 1O2 is a dominant tumoricidal component that is generated during the photodynamic therapy (PDT). While type II photodynamic action generates not only 1O2 but also other reactive species, endoperoxides release pure 1O2 upon mild exposure to heat and, hence, are considered to be beneficial compounds for research purposes. Concerning target molecules, 1O2 preferentially reacts with unsaturated fatty acids to produce lipid peroxidation. Enzymes that contain a reactive cysteine group at the catalytic center are vulnerable to 1O2 exposure. Guanine base in nucleic acids is also susceptible to oxidative modification, and cells carrying DNA with oxidized guanine units may experience mutations. Since 1O2 is produced in various physiological reactions in addition to photodynamic reactions, overcoming technical challenges related to its detection and methods used for its generation would allow its potential functions in biological systems to be better understood.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
DOI：
10.3390/antiox10091448
发表时间：
2021-09-13
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Ahn YJ;Kim H
通讯作者：
Kim H
影响因子：
10.2
作者：
Chin, Yu-Cheng;Yang, Li-Xing;Hsu, Fei-Ting;Hsu, Che-Wei;Chang, Te-Wei;Chen, Hsi-Ying;Chen, Linda Yen-Chien;Chia, Zi Chun;Hung, Chun-Hua;Su, Wu-Chou;Chiu, Yi-Chun;Huang, Chih-Chia;Liao, Mei-Yi
通讯作者：
Liao, Mei-Yi
影响因子：
4.7
作者：
通讯作者：
--
DOI：
10.1083/jcb.201102095
发表时间：
2011-07-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Finkel T
通讯作者：
Finkel T