Lutein as a Modulator of Oxidative Stress-Mediated Inflammatory Diseases.
Lutein as a Modulator of Oxidative Stress-Mediated Inflammatory Diseases.
复制标题
叶黄素作为氧化应激介导的炎症性疾病的调节剂。
DOI：
10.3390/antiox10091448
复制
发表时间：
2021-09-13
期刊：
影响因子：
--
通讯作者：
Kim H
中科院分区：
文献类型：
--
作者：
Ahn YJ;Kim H
叶黄素是一种叶黄素类胡萝卜素，从各种食物中获得，如深绿色多叶蔬菜和蛋黄。叶黄素具有抗氧化活性，并清除活性氧，如单线态氧和脂质过氧自由基。氧化应激激活炎症介质，导致代谢性和炎症性疾病的发展。因此，最近的基础和临床研究已经调查了叶黄素的抗炎作用的基础上，其抗氧化活性和氧化剂敏感的炎症信号通路的调制。叶黄素抑制核因子-kB和信号转导子和转录激活子3的激活，以及抑制炎性细胞因子（白细胞介素-1 β、白细胞介素-6、单核细胞趋化蛋白-1、肿瘤坏死因子-α）和炎性酶（环氧合酶-2、诱导型一氧化氮合酶）的诱导。它还维持内源性抗氧化剂（谷胱甘肽）的含量，并激活核因子红细胞2相关因子2（Nrf 2）和Nrf 2信号相关的抗氧化酶（血红素加氧酶-1、NAD（P）H：醌氧化还原酶1、谷胱甘肽-s-转移酶、谷胱甘肽过氧化物酶、超氧化物歧化酶、过氧化氢酶）。在这篇综述中，我们讨论了目前的知识有关的抗炎功能的叶黄素对炎症性疾病在各种器官，包括神经退行性疾病，眼科疾病，糖尿病视网膜病变，骨质疏松症，心血管疾病，皮肤疾病，肝损伤，肥胖症，和结肠疾病。
Lutein is a xanthophyll carotenoid obtained from various foods, such as dark green leafy vegetables and egg yolk. Lutein has antioxidant activity and scavenges reactive oxygen species such as singlet oxygen and lipid peroxy radicals. Oxidative stress activates inflammatory mediators, leading to the development of metabolic and inflammatory diseases. Thus, recent basic and clinical studies have investigated the anti-inflammatory effects of lutein based on its antioxidant activity and modulation of oxidant-sensitive inflammatory signaling pathways. Lutein suppresses activation of nuclear factor-kB and signal transducer and activator of transcription 3, and induction of inflammatory cytokines (interleukin-1β, interleukin-6, monocyte chemoattratant protein-1, tumor necrosis factor-α) and inflammatory enzymes (cyclooxygenase-2, inducible nitric oxide synthase). It also maintains the content of endogenous antioxidant (glutathione) and activates nuclear factor erythroid 2–related factor 2 (Nrf2) and Nrf2 signaling-related antioxidant enzymes (hemeoxygenase-1, NAD(P)H: quinone oxidoreductase 1, glutathione-s-transferase, glutathione peroxidase, superoxide dismutase, catalase). In this review, we have discussed the current knowledge regarding the anti-inflammatory function of lutein against inflammatory diseases in various organs, including neurodegenerative disorders, eye diseases, diabetic retinopathy, osteoporosis, cardiovascular diseases, skin diseases, liver injury, obesity, and colon diseases.
登录
查看更多内容
影响因子：
13.7
作者：
Chang JR;Koo E;Agrón E;Hallak J;Clemons T;Azar D;Sperduto RD;Ferris FL 3rd;Chew EY;Age-Related Eye Disease Study Group
通讯作者：
Age-Related Eye Disease Study Group
影响因子：
6.2
作者：
Dai, Zhaoli;Wang, Renwei;Ang, Li-Wei;Low, Yen-Ling;Yuan, Jian-Min;Koh, Woon-Puay
通讯作者：
Koh, Woon-Puay
影响因子：
7.7
作者：
Ford, ES;Mokdad, AH;Brown, DW
通讯作者：
Brown, DW
影响因子：
6.5
作者：
González, S;Astner, S;Pathak, MA
通讯作者：
Pathak, MA
影响因子：
3.7
作者：
Beier JI;McClain CJ
通讯作者：
McClain CJ