Molecular genetics and imaging technologies for circuit-based neuroanatomy.

Molecular genetics and imaging technologies for circuit-based neuroanatomy.
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DOI:
10.1038/nature08536
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发表时间:
2009-10-15
期刊:
影响因子:
64.8
通讯作者:
--
中科院分区:
综合性期刊1区
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--
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脑功能来自于不同神经元之间建立的形态、空间组织和连接模式。从历史上看,神经元结构预测功能的概念源于经典的组织学染色和神经元示踪方法。分子遗传学和成像技术的最新进展已经开始揭示以前无法获得的关于活脑中功能回路连接模式和突触亚细胞组织的细节。一个复杂的分子和遗传“工具箱”,加上新的方法,在光学和电子显微镜提供了一个不断扩大的阵列技术探测神经解剖和功能。
Brain function emerges from the morphologies, spatial organization, and patterns of connectivity established between diverse sets of neurons. Historically, the notion that neuronal structure predicts function stemmed from classic histological staining and neuronal tracing methods. Recent advances in molecular genetic and imaging technologies have begun to reveal previously unattainable details about patterns of functional circuit connectivity and the subcellular organization of synapses in the living brain. A sophisticated molecular and genetic “tool box” coupled with new methods in optical and electron microscopy provide an expanding array of techniques for probing neural anatomy and function.
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