Seroprevalence of SARS-CoV-2 among the staff and patients of a French cancer centre after first lockdown: The canSEROcov study.
Seroprevalence of SARS-CoV-2 among the staff and patients of a French cancer centre after first lockdown: The canSEROcov study.
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DOI：
10.1016/j.ejca.2021.02.027
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Ghiringhelli F
中科院分区：
文献类型：
--
作者：
Ladoire S;Goussot V;Redersdorff E;Cueff A;Ballot E;Truntzer C;Ayati S;Bengrine-Lefevre L;Bremaud N;Coudert B;Desmoulins I;Favier L;Fraisse C;Fumet JD;Hanu R;Hennequin A;Hervieu A;Ilie S;Kaderbhai C;Lagrange A;Martin N;Mazilu I;Mayeur D;Palmier R;Simonet-Lamm AL;Vincent J;Zanetta S;Arnould L;Coutant C;Bertaut A;Ghiringhelli F
鉴于严重急性呼吸系统综合征冠状病毒-2 （SARS-CoV-2）感染癌症患者的潜在严重性，流行病学数据对于评估癌症中心患者和工作人员之间的病毒传播至关重要。我们进行了一项前瞻性研究，调查在法国第一次全国封锁期结束时，一家大型癌症中心的工作人员和癌症患者中SARS-CoV-2抗体的血清阳性率，并确定与SARS-CoV-2感染风险相关的因素。第一次封锁后，所有医务人员和非医务人员以及肿瘤内科的所有患者都被邀请在2020年5月11日至6月30日期间接受SARS-CoV-2血清学检测。所有参与者还被邀请完成一份调查问卷，收集有关他们的生活和工作条件以及患者在封锁期间医疗管理的数据。共纳入1,674名受试者（663名工作人员，1011名患者）。工作人员（1.8%）和患者（1.7%）的血清阳性率都很低，尽管患者中有更多严重形式的高风险特征。在我们的分析中测试的危险因素（工作或生活条件、合并症、封锁期间的管理特征）均未发现与工作人员或患者的血清阳性率有统计学关联。工作人员和患者在有症状和无症状受试者的比例上无显著差异。在工作人员和患者中，只有发热、嗅觉丧失和味觉丧失在血清阳性患者中更为常见。我们报告了一家大型癌症护理中心的工作人员（护理人员和非护理人员）和患者中SARS-CoV-2抗体的血清阳性率非常低，该中心实施了严格的卫生、个人保护和社交距离措施。
In view of the potential gravity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection for patients with cancer, epidemiological data are vital to assess virus circulation among patients and staff of cancer centres. We performed a prospective study to investigate seroprevalence of SARS-CoV-2 antibodies among staff and patients with cancer at a large cancer centre, at the end of the period of first national lockdown in France and to determine factors associated with the risk of SARS-CoV-2 infection. After the first lockdown, all medical and non-medical staff, as well as all patients attending the medical oncology department were invited to undergo serological testing for SARS-CoV-2 between 11 May and 30 June 2020. All participants were also invited to complete a questionnaire collecting data about their living and working conditions, and for patients, medical management during lockdown. A total of 1,674 subjects (663 staff members, 1011 patients) were included. Seroprevalence was low in both staff (1.8%) and patients (1.7%), despite more features of high risk for severe forms among patients. None of the risk factors tested in our analysis (working or living conditions, comorbidities, management characteristics during lockdown) was found to be statistically associated with seroprevalence in either staff or patients. There was no significant difference in the proportion of symptomatic and asymptomatic subjects between staff and patients. Only fever, loss of smell, and loss of taste were significantly more frequent among seropositive patients, in both staff and patients. We report very low seroprevalence of antibodies against SARS-CoV-2 in the staff (caregiving and non-caregiving) and patients of a large cancer care centre in which strict hygiene, personal protection, and social distancing measures were implemented.
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影响因子：
8.4
作者：
Elkrief, Arielle;Desilets, Antoine;Routy, Bertrand
通讯作者：
Routy, Bertrand
DOI：
10.1016/j.ejca.2020.09.035
发表时间：
2020-12
期刊：
European journal of cancer (Oxford, England : 1990)
影响因子：
--
作者：
Lièvre A;Turpin A;Ray-Coquard I;Le Malicot K;Thariat J;Ahle G;Neuzillet C;Paoletti X;Bouché O;Aldabbagh K;Michel P;Debieuvre D;Canellas A;Wislez M;Laurent L;Mabro M;Colle R;Hardy-Bessard AC;Mansi L;Colomba E;Bourhis J;Gorphe P;Pointreau Y;Idbaih A;Ursu R;Di Stefano AL;Zalcman G;Aparicio T;GCO-002 CACOVID-19 collaborators/investigators
通讯作者：
GCO-002 CACOVID-19 collaborators/investigators
影响因子：
45.3
作者：
Berghoff, Anna S.;Gansterer, Margaretha;Preusser, Matthias
通讯作者：
Preusser, Matthias
影响因子：
28.2
作者：
Dai, Mengyuan;Liu, Dianbo;Cai, Hongbing
通讯作者：
Cai, Hongbing
DOI：
10.1016/j.annonc.2020.10.473
发表时间：
2021-01
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Marra A;Generali D;Zagami P;Cervoni V;Gandini S;Venturini S;Morganti S;Passerini R;Orecchia R;Curigliano G
通讯作者：
Curigliano G