Cognitive enhancement as a pharmacotherapy target for stimulant addiction.
Cognitive enhancement as a pharmacotherapy target for stimulant addiction.
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DOI：
10.1111/j.1360-0443.2009.02791.x
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Sofuoglu M
中科院分区：
文献类型：
--
作者：
Sofuoglu M
No medications have been proven to be effective for cocaine and methamphetamine addiction. Attenuation of drug reward has been the main strategy for medications development, but this approach has not led to effective treatments. Thus, there is a need to identify novel treatment targets in addition to the brain reward system. To propose a novel treatment strategy for stimulant addiction that will focus on medications enhancing cognitive function and attenuating drug reward. Preclinical and clinical literature on potential use of cognitive enhancers for stimulant addiction pharmacotherapy was reviewed. Cocaine and methamphetamine users show significant cognitive impairments, especially in attention, working memory and response inhibition functions. The cognitive impairments seem to be predictive of poor treatment retention and outcome. Medications targeting acetylcholine (Ach) and norepinephrine (NE) are particularly well-suited for enhancing cognitive function in stimulant users. Many cholinergic and noradrenergic medications are on the market, have a good safety profile, and low abuse potential. These include galantamine, donepezil, and rivastigmine (cholinesterase inhibitors), varenicline (partial nicotine agonist), guanfacine (alpha2-adrenergic agonist), and atomoxetine (norepinephrine transporter inhibitor). Future clinical studies optimally designed to measure cognitive function as well as drug use behavior would be needed to test the efficacy of these cognitive enhancers for stimulant addiction.
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影响因子：
4.2
作者：
Aharonovich, E;Hasin, DS;Nunes, EV
通讯作者：
Nunes, EV
影响因子：
3
作者：
Camicioli, Richard;Gauthier, Serge
通讯作者：
Gauthier, Serge
影响因子：
4.2
作者：
Aharonovich, E;Nunes, E;Hasin, D
通讯作者：
Hasin, D
DOI：
10.1196/annals.1417.007
发表时间：
2008-01-01
期刊：
MOLECULAR AND BIOPHYSICAL MECHANISMS OF AROUSAL, ALERTNESS, AND ATTENTION
影响因子：
--
作者：
Brennan, Avis R.;Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
DOI：
10.1126/science.1121218
发表时间：
2006-02-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chamberlain SR;Müller U;Blackwell AD;Clark L;Robbins TW;Sahakian BJ
通讯作者：
Sahakian BJ