Abacus: a computational tool for extracting and pre-processing spectral count data for label-free quantitative proteomic analysis.
Abacus: a computational tool for extracting and pre-processing spectral count data for label-free quantitative proteomic analysis.
复制标题
算:一种用于提取和预处理光谱计数数据的计算工具,用于无标签的定量蛋白质组学分析。
DOI:
10.1002/pmic.201000650
复制
发表时间:
2011-04
期刊:
影响因子:
3.4
通讯作者:
Nesvizhskii, Alexey I.
中科院分区:
文献类型:
--
作者:
Fermin, Damian;Basrur, Venkatesha;Yocum, Anastasia K.;Nesvizhskii, Alexey I.
We describe Abacus, a computational tool for extracting spectral counts from tandem mass spectrometry based proteomic datasets. The program aggregates data from multiple experiments, adjusts spectral counts to accurately account for peptides shared across multiple proteins, and performs common normalization steps. It can also output the spectral count data at the gene level, thus simplifying the integration and comparison between gene and protein expression data. Abacus is compatible with the widely used Trans-Proteomic Pipeline suite of tools and comes with a graphical user interface making it easy to interact with the program. The main aim of Abacus is to streamline the analysis of spectral count data by providing an automated, easy to use solution for extracting this information from proteomic datasets for subsequent, more sophisticated statistical analysis.
登录
查看更多内容
影响因子:
3.4
作者:
Deutsch, Eric W.;Mendoza, Luis;Shteynberg, David;Farrah, Terry;Lam, Henry;Tasman, Natalie;Sun, Zhi;Nilsson, Erik;Pratt, Brian;Prazen, Bryan;Eng, Jimmy K.;Martin, Daniel B.;Nesvizhskii, Alexey I.;Aebersold, Ruedi
通讯作者:
Aebersold, Ruedi
DOI:
10.1073/pnas.0907654107
发表时间:
2010-07-06
影响因子:
11.1
作者:
Gerster, Sarah;Qeli, Ermir;Buehlmann, Peter
通讯作者:
Buehlmann, Peter
影响因子:
9.9
作者:
Li, Jing;Zimmerman, Lisa J.;Park, Byung-Hoon;Tabb, David L.;Liebler, Daniel C.;Zhang, Bing
通讯作者:
Zhang, Bing
影响因子:
3.4
作者:
Searle, Brian C.
通讯作者:
Searle, Brian C.
DOI:
10.1093/bioinformatics/btp692
发表时间:
2010-02-15
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
作者:
Li B;Ruotti V;Stewart RM;Thomson JA;Dewey CN
通讯作者:
Dewey CN