Ready-to-Use Therapeutic Foods (RUTFs) Based on Local Recipes Are as Efficacious and Have a Higher Acceptability than a Standard Peanut-Based RUTF: A Randomized Controlled Trial in Indonesia.
Ready-to-Use Therapeutic Foods (RUTFs) Based on Local Recipes Are as Efficacious and Have a Higher Acceptability than a Standard Peanut-Based RUTF: A Randomized Controlled Trial in Indonesia.
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DOI：
10.3390/nu15143166
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发表时间：
2023-07-17
期刊：
影响因子：
5.9
通讯作者：
Wieringa, Frank T.
中科院分区：
文献类型：
--
作者：
Rachmadewi, Asrinisa;Soekarjo, Damayanti D.;Bait, Blandina Rosalina;Suryantan, Julia;Noor, Rivani;Rah, Jee Hyun;Wieringa, Frank T.
关键词：
为了加强印度尼西亚严重急性营养不良 (SAM) 的社区治疗，需要本地生产的即用治疗食品 (RUTF)，但缺乏有关其可接受性和有效性的数据。我们对 302 名患有无并发症 SAM 的儿童（6-59 个月大）进行了一项单独随机对照试验，接受 8 周的标准 RUTF (CON) 或使用当地可用成分生产的四种替代 RUTF 之一：大豆 (SOY)、绿豆 (MUN1、MUN2) 或花生 (PEA)。主要结果是体重增加和产品可接受性。儿童平均消耗 2.2 公斤标准 RUTF，但最多消耗 4.5 公斤当地产品（MUN2，p < 0.05）。各组的平均体重增加没有差异 (p > 0.05)。在控制消费量的情况下，接受 CON 或 SOY RUTF 产品的儿童每天体重增加 >2 克/公斤体重 (BW)，而接受其他 RUTF 产品的儿童则为 1.6 克/公斤体重/天 (p > 0.05)。总体辍学率为 29.1%，范围从 21.3% (MUN2) 到 38.3% (CON，p > 0.05)。 CON 组的平均退出时间为 19 天，明显短于 PEA 组（33.6 天，p < 0.05）。因此，在体重增加没有差异且接受度更高的情况下，有必要在印度尼西亚开发本地生产的 RUTF，以加强 SAM 的社区治疗。
To strengthen community-based treatment of severe acute malnutrition (SAM) in Indonesia, locally produced ready-to-use therapeutic foods (RUTFs) are needed, but data on their acceptability and effectiveness are lacking. We conducted an individually randomized controlled trial in 302 children (6–59 months old) with uncomplicated SAM receiving 8 weeks of a standard RUTF (CON) or one of four alternative RUTFs produced with locally available ingredients: soybean (SOY), mungbean (MUN1, MUN2) or peanuts (PEA). The main outcomes were weight gain and product acceptability. Children consumed on average 2.2 kg of standard RUTF, but up to 4.5 kg of the local products (MUN2, p < 0.05). Mean weight gain did not differ across the groups (p > 0.05). Controlled for consumption, children receiving either CON or SOY RUTF gained >2 g/kg body weight (BW)/day compared with 1.6 g/kg BW/day in children receiving the other RUTF products (p > 0.05). Overall drop-out was 29.1%, ranging from 21.3% (MUN2) to 38.3% (CON, p > 0.05). Mean time to drop out was 19 days in the CON group, significantly shorter than in the PEA group (33.6 days, p < 0.05). Thus, with no difference in weight gain and better acceptance, the development of locally produced RUTFs in Indonesia is warranted to strengthen the community-based treatment of SAM.
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