Utilization of T1-Mapping for the pelvic and thigh muscles in Duchenne Muscular Dystrophy: a quantitative biomarker for disease involvement and correlation with clinical assessments.
Utilization of T1-Mapping for the pelvic and thigh muscles in Duchenne Muscular Dystrophy: a quantitative biomarker for disease involvement and correlation with clinical assessments.
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T1-Mapping 在杜氏肌营养不良症中对骨盆和大腿肌肉的利用：疾病参与的定量生物标志物以及与临床评估的相关性
DOI：
10.1186/s12891-022-05640-y
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发表时间：
2022-07-16
影响因子：
2.3
通讯作者：
中科院分区：
文献类型：
--
作者：
目前对Duchenne型肌营养不良症（DMD）的T1-Mapping检测的疾病分布和严重程度知之甚少。此外，骨骼肌T1值和临床评估之间的相关性研究较少。因此，本研究的目的是通过对髋关节和大腿肌肉的详细分析，探讨定量T1-mapping在检测疾病累及程度方面的作用，进一步探讨T1-mapping对DMD临床状态的预测价值。共纳入92例DMD患者。对19例右侧骨盆和大腿肌肉进行脂肪浸润分级，并分别测量其轴位T1加权像（T1 WI）和T1图的T1值，评价并比较病变分布和严重程度。临床评估包括年龄、身高、体重、BMI、轮椅使用、定时功能测试、NorthStar动态评估（NSAA）评分、血清肌酸激酶（CK）水平。将肌肉T1值与临床评估进行相关性分析。对T1值与运动功能的独立相关性进行多元线性回归分析。臀大肌的T1值最低，股薄肌的T1值最高。T1值随T1 WI脂肪浸润程度的增加而降低（P < 0.001）。T1值的降低与年龄、身高、体重、轮椅使用、定时功能测试的增加有关（P < 0.05）。T1值与NSAA（r = 0.232-0.721，P < 0.05）和CK（r = 0.208-0.491，P < 0.05）呈正相关。臀大肌、筋膜张肌、股外侧肌、股中间肌、股内侧肌和大收肌的T1值与临床运动功能测试独立相关（P < 0.05）。组间相关系数（ICC）分析和Bland-Altman图显示T1值感兴趣区（ROI）测量的评估者间可靠性极佳。T1-Mapping可作为DMD疾病累及的定量生物标志物，进一步评估疾病严重程度和预测运动功能。在线版本包含补充材料，可通过10.1186/s12891-022-05640-y获得。
Little is known about the disease distribution and severity detected by T1-mapping in Duchenne muscular dystrophy (DMD). Furthermore, the correlation between skeletal muscle T1-values and clinical assessments is less studied. Hence, the purposes of our study are to investigate quantitative T1-mapping in detecting the degree of disease involvement by detailed analyzing the hip and thigh muscle, future exploring the predicting value of T1-mapping for the clinical status of DMD. Ninety-two DMD patients were included. Grading fat infiltration and measuring the T1-values of 19 pelvic and thigh muscles (right side) in axial T1-weighted images (T1WI) and T1-maps, respectively, the disease distribution and severity were evaluated and compared. Clinical assessments included age, height, weight, BMI, wheelchair use, timed functional tests, NorthStar ambulatory assessment (NSAA) score, serum creatine kinase (CK) level. Correlation analysis were performed between the muscle T1-value and clinical assessments. Multiple linear regression analysis was conducted for the independent association of T1-value and motor function. The gluteus maximus had the lowest T1-value, and the gracilis had the highest T1-value. T1-value decreased as the grade of fat infiltration increased scored by T1WI (P < 0.001). The decreasing of T1-values was correlated with the increase of age, height, weight, wheelchair use, and timed functional tests (P < 0.05). T1-value correlated with NSAA (r = 0.232-0.721, P < 0.05) and CK (r = 0.208-0.491, P < 0.05) positively. T1-value of gluteus maximus, tensor fascia, vastus lateralis, vastus intermedius, vastus medialis, and adductor magnus was independently associated with the clinical motor function tests (P < 0.05). Interclass correlation coefficient (ICC) analysis and Bland-Altman plots showed excellent inter-rater reliability of T1-value region of interest (ROI) measurements. T1-mapping can be used as a quantitative biomarker for disease involvement, further assessing the disease severity and predicting motor function in DMD. The online version contains supplementary material available at 10.1186/s12891-022-05640-y.
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DOI：
10.3390/life11070648
发表时间：
2021-07-04
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
Reid AL;Alexander MS
通讯作者：
Alexander MS
影响因子：
6
作者：
Barnard, Alison M.;Lott, Donovan J.;Walter, Glenn A.
通讯作者：
Walter, Glenn A.
影响因子：
5.7
作者：
Chrzanowski, Stephen M.;Darras, Basil T.;Rutkove, Seward B.
通讯作者：
Rutkove, Seward B.
影响因子：
4.6
作者：
Marty, Benjamin;Carlier, Pierre G.
通讯作者：
Carlier, Pierre G.
影响因子：
3.9
作者：
Nascimento Osorio, A.;Medina Cantillo, J.;Vilchez Padilla, J. J.
通讯作者：
Vilchez Padilla, J. J.