Direct numerical simulation of transitional flow in a stenosed carotid bifurcation.
Direct numerical simulation of transitional flow in a stenosed carotid bifurcation.
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DOI：
10.1016/j.jbiomech.2008.03.038
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发表时间：
2008-08-07
影响因子：
2.4
通讯作者：
Loth, Francis
中科院分区：
文献类型：
--
作者：
Lee, Seung E.;Lee, Sang-Wook;Fischer, Paul F.;Bassiouny, Hisham S.;Loth, Francis
关键词：
采用谱元法对狭窄的颈动脉分叉处的血流动力学进行了数值模拟。脉动入口条件基于血流速度的体内彩色多普勒超声测量。结果显示，血流的过渡或弱湍流状态，其特征在于在收缩期和层流在狭窄后的颈内动脉区域的快速速度和压力波动。在收缩减速期，狭窄下游的高频旋涡脱落最大。速度波动的频率在100-300 Hz的可听范围内。与健康颈动脉相比，狭窄内的瞬时壁剪切应力在收缩期（~25-45 Pa）相对较高。此外，由于在内壁上的流动分离，存在壁面切应力的高空间梯度。在颈内动脉狭窄远端观察到振荡性血流逆转和低压。这项研究预测了复杂的流场，湍流水平和生物力学应力的分布存在于狭窄的颈动脉在体内。
The blood flow dynamics of a stenosed, subject-specific, carotid bifurcation were numerically simulated using the spectral element method. Pulsatile inlet conditions were based on in vivo color Doppler ultrasound measurements of blood velocity. The results demonstrated the transitional or weakly turbulent state of the blood flow, which featured rapid velocity and pressure fluctuations in the post-stenotic region of the internal carotid artery during systole and laminar flow during diastole. High-frequency vortex shedding was greatest downstream of the stenosis during the deceleration phase of systole. Velocity fluctuations had a frequency within the audible range of 100–300 Hz. Instantaneous wall shear stress within the stenosis was relatively high during systole (~25-45 Pa) compared to that in a healthy carotid. In addition, high spatial gradients of wall shear stress were present due to flow separation on the inner wall. Oscillatory flow reversal and low pressure were observed distal to the stenosis in the internal carotid artery. This study predicts the complex flow field, the turbulence levels and the distribution of the biomechanical stresses present in vivo within a stenosed carotid artery.
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影响因子：
2
作者：
Lee, Sang-Wook;Smith, David S.;Bassiouny, Hisham S.
通讯作者：
Bassiouny, Hisham S.
DOI：
10.1073/pnas.83.7.2114
发表时间：
1986-04-01
影响因子：
11.1
作者：
DAVIES, PF;REMUZZI, A;GIMBRONE, MA
通讯作者：
GIMBRONE, MA
影响因子：
3.7
作者：
He, S;Jackson, JD
通讯作者：
Jackson, JD
DOI：
10.1016/j.cma.2006.10.015
发表时间：
2007-01-01
影响因子：
7.2
作者：
Fischer, Paul F.;Loth, Francis;Bassiouny, Hisham S.
通讯作者：
Bassiouny, Hisham S.
影响因子：
3.1
作者：
HELLUMS, JD
通讯作者：
HELLUMS, JD