Dominant Mycobacterium tuberculosis lineages in elderly patients born in Norway.
Dominant Mycobacterium tuberculosis lineages in elderly patients born in Norway.
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DOI：
10.1371/journal.pone.0008373
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发表时间：
2009-12-18
期刊：
影响因子：
3.7
通讯作者：
Dahle UR
中科院分区：
文献类型：
--
作者：
Kinander W;Bruvik T;Dahle UR
在上一个世纪，挪威结核病发病率很高，但没有进行分子流行病学研究，这些以前流行的菌株在过去几十年中已经消失。目前，挪威土著人中的结核病正处于消除阶段，仍然不知道哪种类型的M。结核病在世纪后半叶得到了有效控制。然而，许多出生在挪威的老年人仍然患有结核病，这些结核病不能与进口或最近传播的M。结核因此，这些病例中的大多数是几十年前传播的疾病重新激活的结果。共检出213株M.在本研究中，对1998-2005年期间从1950年以前出生于挪威的患者中分离的结核病进行了基因分型。结果表明，高度同质的M。结核病患者中。共有40%属于T家族，35%被分配到T1亚家族（T2 = 0，93%，T3 = 1，4%和T4 = 2，3%）。 其中哈勒姆家族占35%，哈勒姆1家族占15%，哈勒姆3家族占19%。剩下的25%属于15个不同的家庭。RFLP模式表明，分离株不是最近传播的结果，而是代表了几十年前在挪威明显占主导地位的成熟菌株。对M.结核病在1950年以前出生于挪威的患者中大量存在。分枝肺结核病例是1994年以前感染的疾病复发，可能已潜伏了几十年。因此，目前的研究表明，T1，哈勒姆1，和哈勒姆3家庭可能是常见的挪威，当结核病代表了一个严重的公共卫生威胁在上半个世纪。
During the previous century Norway had a high incidence of tuberculosis, but no molecular epidemiological studies could be performed and these previously epidemic strains have been disappearing during the last decades. Currently, tuberculosis among native Norwegians is in the elimination phase, and it is still not known what type of M. tuberculosis was so efficiently controlled during the second half of the 20th century. However, many elderly Norwegian-born people still develop TB that cannot be clustered to imported or recently transmitted strains of M. tuberculosis. Thus, the majority of these cases are results of reactivation of disease that was transmitted many decades ago. A total of 213 strains of M. tuberculosis isolated during 1998–2005, from patients born in Norway before 1950 were genotyped in the current study. The findings demonstrated a highly homogenous M. tuberculosis population among the patients. A total of 40% belonged to the T-family, were 35% were assigned to T1 sub- family (T2 = 0, 93%, T3 = 1, 4% and T4 = 2, 3%). As many as 35% of the isolates belonged to the Haarlem family, were 15% were assigned to Haarlem1 and 19% to Haarlem3. The remaining 25% belonged to 15 different other families. The RFLP-patterns indicated that the isolates were not a result of recent transmission, but rather represented well established strains that apparently dominated in Norway many decades ago. The T 1, Haarlem 1, and Haarlem 3 families of M. tuberculosis were abundant among patients born in Norway before 1950. The M. tuberculosis cases represented reactivated disease that had been acquired before 1994 and were likely to have been latent for several decades. Thus, the current study indicated that the T 1, Haarlem 1, and Haarlem 3 families may have been common in Norway, when tuberculosis represented a serious public health threat during the first half of the 20th century.
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影响因子：
3.7
作者：
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通讯作者：
Gao Q
影响因子：
2.8
作者：
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通讯作者：
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影响因子：
9.6
作者：
Velayati, Ali Akbar;Masjedi, Mohammad Reza;Hoffner, Sven Eric
通讯作者：
Hoffner, Sven Eric
影响因子：
9.4
作者：
Kamerbeek, J;Schouls, L;vanEmbden, J
通讯作者：
vanEmbden, J
影响因子：
3.1
作者：
DUNN, PL;NORTH, RJ
通讯作者：
NORTH, RJ