Can genome engineering be used to target cancer-associated enhancers?
Can genome engineering be used to target cancer-associated enhancers?
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DOI：
10.2217/epi.14.30
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发表时间：
2014
期刊：
影响因子：
3.8
通讯作者：
Farnham PJ
中科院分区：
文献类型：
--
作者：
Grimmer MR;Farnham PJ
Transcriptional misregulation is involved in the development of many diseases, especially neoplastic transformation. Distal regulatory elements, such as enhancers, play a major role in specifying cell-specific transcription patterns in both normal and diseased tissues, suggesting that enhancers may be prime targets for therapeutic intervention. By focusing on modulating gene regulation mediated by cell type-specific enhancers, there is hope that normal epigenetic patterning in an affected tissue could be restored with fewer side effects than observed with treatments employing relatively nonspecific inhibitors such as epigenetic drugs. New methods employing genomic nucleases and site-specific epigenetic regulators targeted to specific genomic regions, using either artificial DNA-binding proteins or RNA–DNA interactions, may allow precise genome engineering at enhancers. However, this field is still in its infancy and further refinements that increase specificity and efficiency are clearly required.
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通讯作者：
Wysocka, Joanna
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通讯作者：
Coetzee GA
影响因子：
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