Effect of Point-Spread Function Reconstruction for Indeterminate PSMA-RADS-3A Lesions on PSMA-Targeted PET Imaging of Men with Prostate Cancer.
Effect of Point-Spread Function Reconstruction for Indeterminate PSMA-RADS-3A Lesions on PSMA-Targeted PET Imaging of Men with Prostate Cancer.
复制标题
DOI：
10.3390/diagnostics11040665
复制
发表时间：
2021-04-07
期刊：
影响因子：
--
通讯作者：
Rowe SP
中科院分区：
文献类型：
--
作者：
Khatri W;Chung HW;Werner RA;Leal JP;Pienta KJ;Lodge MA;Gorin MA;Pomper MG;Rowe SP
Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is emerging as an important modality for imaging patients with prostate cancer (PCa). As with any imaging modality, indeterminate findings will arise. The PSMA reporting and data system (PSMA-RADS) version 1.0 codifies indeterminate soft tissue findings with the PSMA-RADS-3A moniker. We investigated the role of point-spread function (PSF) reconstructions on categorization of PSMA-RADS-3A lesions. Methods: This was a post hoc analysis of an institutional review board approved prospective trial. Around 60 min after the administration of 333 MBq (9 mCi) of PSMA-targeted 18F-DCFPyL, patients underwent PET/computed tomography (CT) acquisitions from the mid-thighs to the skull vertex. The PET data were reconstructed with and without PSF. Scans were categorized according to PSMA-RADS version 1.0, and all PSMA-RADS-3A lesions on non-PSF images were re-evaluated to determine if any could be re-categorized as PSMA-RADS-4. The maximum standardized uptake values (SUVs) of the lesions, mean SUVs of blood pool, and the ratios of those values were determined. Results: A total of 171 PSMA-RADS-3A lesions were identified in 30 patients for whom both PSF reconstructions and cross-sectional imaging follow-up were available. A total of 13/171 (7.6%) were re-categorized as PSMA-RADS-4 lesions with PSF reconstructions. A total of 112/171 (65.5%) were found on follow-up to be true positive for PCa, with all 13 of the re-categorized lesions being true positive on follow-up. The lesions that were re-categorized trended towards having higher SUVmax-lesion and SUVmax-lesion/SUVmean-blood-pool metrics, although these relationships were not statistically significant. Conclusions: The use of PSF reconstructions for 18F-DCFPyL PET can allow the appropriate re-categorization of a small number of indeterminate PSMA-RADS-3A soft tissue lesions as more definitive PSMA-RADS-4 lesions. The routine use of PSF reconstructions for PSMA-targeted PET may be of value at those sites that utilize this technology.
登录
查看更多内容
影响因子：
--
作者：
Reyes DK;Pienta KJ
通讯作者：
Pienta KJ
DOI：
10.3390/diagnostics10090622
发表时间：
2020-08-22
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Moazemi S;Khurshid Z;Erle A;Lütje S;Essler M;Schultz T;Bundschuh RA
通讯作者：
Bundschuh RA
影响因子：
3.3
作者：
Perner, Sven;Hofer, Matthias D.;Rubin, Mark A.
通讯作者：
Rubin, Mark A.
影响因子：
4.8
作者：
Rowe SP;Gorin MA;Allaf ME;Pienta KJ;Tran PT;Pomper MG;Ross AE;Cho SY
通讯作者：
Cho SY
影响因子：
9.3
作者：
Rowe, Steven P.;Pienta, Kenneth J.;Gorin, Michael A.
通讯作者：
Gorin, Michael A.