The Default Mode Network is functionally and structurally disrupted in amnestic mild cognitive impairment - a bimodal MEG-DTI study.
The Default Mode Network is functionally and structurally disrupted in amnestic mild cognitive impairment - a bimodal MEG-DTI study.
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DOI：
10.1016/j.nicl.2014.09.004
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Maestú F
中科院分区：
文献类型：
--
作者：
Garcés P;Angel Pineda-Pardo J;Canuet L;Aurtenetxe S;López ME;Marcos A;Yus M;Llanero-Luque M;Del-Pozo F;Sancho M;Maestú F
在过去的几年里，一些关于轻度认知障碍（MCI）和阿尔茨海默病（AD）的研究报告了默认模式网络（DMN）缺陷。这个网络正在引起AD社区越来越多的兴趣，因为它似乎在认知功能和β淀粉样蛋白沉积中发挥重要作用。特别注意不同的DMN区域如何使用功能或结构连接性连接。为此，大多数研究使用功能性磁共振成像（fMRI），正电子发射断层扫描（PET）或扩散张量成像（DTI）。在这项研究中，我们评估了（1）静息状态脑磁图（MEG）的功能连接和（2）DTI的结构连接在26例MCI患者和31名年龄匹配的对照。与对照组相比，MCI组中的DMN在α频带中被功能性破坏，而在δ、θ、β和γ频带中没有发现差异。此外，结构断开可以通过减少分数各向异性沿着道连接不同的DMN区域进行评估。这表明DMN功能和解剖学分离可能代表MCI的核心特征。我们研究了MCI患者和对照组的功能和结构连接。我们关注的是默认模式网络中区域之间的联系。MCI患者静息状态α-带功能连接减少。MCI组的结构连接完整性较低。在两组中，α带的功能和结构连接性相关。
Over the past years, several studies on Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) have reported Default Mode Network (DMN) deficits. This network is attracting increasing interest in the AD community, as it seems to play an important role in cognitive functioning and in beta amyloid deposition. Attention has been particularly drawn to how different DMN regions are connected using functional or structural connectivity. To this end, most studies have used functional Magnetic Resonance Imaging (fMRI), Positron Emission Tomography (PET) or Diffusion Tensor Imaging (DTI). In this study we evaluated (1) functional connectivity from resting state magnetoencephalography (MEG) and (2) structural connectivity from DTI in 26 MCI patients and 31 age-matched controls. Compared to controls, the DMN in the MCI group was functionally disrupted in the alpha band, while no differences were found for delta, theta, beta and gamma frequency bands. In addition, structural disconnection could be assessed through a decreased fractional anisotropy along tracts connecting different DMN regions. This suggests that the DMN functional and anatomical disconnection could represent a core feature of MCI. We studied functional and structural connectivity in MCI patients and controls. We focused on the connections between regions in the Default Mode Network. Resting state alpha-band functional connectivity was decreased in MCI. The integrity of the structural connections was lower for the MCI group. Functional and structural connectivity correlated in the alpha band in both groups.
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DOI：
10.1523/jneurosci.5845-11.2012
发表时间：
2012-03-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bero AW;Bauer AQ;Stewart FR;White BR;Cirrito JR;Raichle ME;Culver JP;Holtzman DM
通讯作者：
Holtzman DM
影响因子：
5.7
作者：
Hindriks, Rikkert;van Putten, Michel J. A. M.
通讯作者：
van Putten, Michel J. A. M.
影响因子：
2.9
作者：
Knyazev, Gennady G.;Slobodskoj-Plusnin, Jaroslav Y.;Pylkova, Liudmila V.
通讯作者：
Pylkova, Liudmila V.
DOI：
10.1073/pnas.0403743101
发表时间：
2004-09-07
影响因子：
11.1
作者：
Johansen-Berg, H;Behrens, TEJ;Matthews, PM
通讯作者：
Matthews, PM
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V