Thujasutchins N and O, two new compounds from the stems and roots of Thuja sutchuenensis

Thujasutchins N and O, two new compounds from the stems and roots of Thuja sutchuenensis
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Thujasutchins N 和 O,两种来自 Thuja stchuenensis 茎和根的新化合物

DOI:
10.1080/14786419.2020.1836627
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发表时间:
2020-10
影响因子:
2.2
通讯作者:
Qiu Sheng-Xiang
Qiu Sheng-Xiang
中科院分区:
化学3区
文献类型:
--
作者:
Wang Miaomiao;Huo Luqiong;Liu Hongxin;Zhao Liyun;Xu Zhifang;Tan Haibo;Qiu Sheng-Xiang

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摘要从崖柏茎和根的乙醇提取物中分离得到两个新的次生代谢产物,其中一个为崖柏烯型倍半萜,命名为崖柏素N(1),另一个为去甲木脂素,命名为崖柏素O(2)。其中,thujasutchin O(2)代表了木脂素共享一个独特的碳还原骨架与新的缩醛功能的第一个例子。通过紫外光谱、红外光谱、高分辨质谱、核磁共振谱和单晶X-射线衍射等多种光谱分析手段,确定了它们的结构。这两种分离株进行了评价,其在体外细胞毒性和抗菌活性。图形摘要
Abstract Two novel secondary metabolites, including one thujopsene-type sesquiterpene designated thujasutchin N (1) and one norlignan named thujasutchin O (2) were obtained from the ethanolic extract of the stems and roots of Thuja sutchuenensis. Among them, thujasutchin O (2) represents the first example of lignan sharing a unique carbon-reduced skeleton with novel acetal functionality. Their structures were unambiguously determined by means of extensively spectroscopic analysis including UV, IR, HRESIMS, NMR, and single crystal X-ray diffraction. Both of the isolates were evaluated for their in vitro cytotoxic and antibacterial activities. Graphical Abstract
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