Treadmill Running Ameliorates Destruction of Articular Cartilage and Subchondral Bone, Not Only Synovitis, in a Rheumatoid Arthritis Rat Model.
Treadmill Running Ameliorates Destruction of Articular Cartilage and Subchondral Bone, Not Only Synovitis, in a Rheumatoid Arthritis Rat Model.
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DOI：
10.3390/ijms19061653
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发表时间：
2018-06-03
影响因子：
5.6
通讯作者：
Kubo T
中科院分区：
文献类型：
--
作者：
Shimomura S;Inoue H;Arai Y;Nakagawa S;Fujii Y;Kishida T;Ichimaru S;Tsuchida S;Shirai T;Ikoma K;Mazda O;Kubo T
我们使用胶原诱导性关节炎 (CIA) 大鼠模型分析了跑步机跑步对类风湿性关节炎 (RA) 关节的影响。将8周龄雄性Dark Agouti大鼠随机分为4组：对照组、跑步机组（从10周龄起每天30分钟，持续4周）、CIA组（8周龄诱导CIA）、CIA+跑步机组。通过组织学分析评估踝关节的破坏。通过μ-CT分析软骨下骨的形态变化。 CIA 治疗引起的滑膜侵袭、关节软骨破坏和骨侵蚀。跑步机跑步改善了这些变化。 CIA大鼠滑膜产生大量肿瘤坏死因子-α和Connexin 43；跑步机跑步显着抑制了生产。在距骨 μ-CT 上，CIA 组的骨体积分数 (BV/TV) 显着下降。骨髓星体积（MSV）（骨质流失指数）显着增加。这些变化通过跑步机跑步得到了显着改善。 CIA 使距骨骨质破坏显着增加，但在跑步机上跑步则可抑制距骨骨质破坏。在抗酒石酸盐酸性磷酸盐和碱性磷酸酶（TRAP/ALP）染色中，跑步机跑步减少了血管翳周围的破骨细胞数量。这些发现表明，CIA 大鼠在跑步机上跑步可抑制滑膜增生和关节破坏。
We analyzed the influence of treadmill running on rheumatoid arthritis (RA) joints using a collagen-induced arthritis (CIA) rat model. Eight-week-old male Dark Agouti rats were randomly divided into four groups: The control group, treadmill group (30 min/day for 4 weeks from 10-weeks-old), CIA group (induced CIA at 8-weeks-old), and CIA + treadmill group. Destruction of the ankle joint was evaluated by histological analyses. Morphological changes of subchondral bone were analyzed by μ-CT. CIA treatment-induced synovial membrane invasion, articular cartilage destruction, and bone erosion. Treadmill running improved these changes. The synovial membrane in CIA rats produced a large amount of tumor necrosis factor-α and Connexin 43; production was significantly suppressed by treadmill running. On μ-CT of the talus, bone volume fraction (BV/TV) was significantly decreased in the CIA group. Marrow star volume (MSV), an index of bone loss, was significantly increased. These changes were significantly improved by treadmill running. Bone destruction in the talus was significantly increased with CIA and was suppressed by treadmill running. On tartrate-resistant acid phosphate and alkaline phosphatase (TRAP/ALP) staining, the number of osteoclasts around the pannus was decreased by treadmill running. These findings indicate that treadmill running in CIA rats inhibited synovial hyperplasia and joint destruction.
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影响因子：
1
作者：
King, Melissa R.;Haussler, Kevin K.;Werpy, Natasha M.
通讯作者：
Werpy, Natasha M.
影响因子：
20.1
作者：
Shanker, AJ;Yamada, K;Saffitz, JE
通讯作者：
Saffitz, JE
影响因子：
2.8
作者：
Bivi, Nicoletta;Pacheco-Costa, Rafael;Brun, Lucas R.;Murphy, Thomas R.;Farlow, Nathan R.;Robling, Alexander G.;Bellido, Teresita;Plotkin, Lilian I.
通讯作者：
Plotkin, Lilian I.
影响因子：
5.5
作者：
Baillet, Athan;Vaillant, Mathieu;Gaudin, Philippe
通讯作者：
Gaudin, Philippe
影响因子：
5.6
作者：
Inoue H;Arai Y;Kishida T;Terauchi R;Honjo K;Nakagawa S;Tsuchida S;Matsuki T;Ueshima K;Fujiwara H;Mazda O;Kubo T
通讯作者：
Kubo T