Diesel exhaust particle-induced airway responses are augmented in obese rats.
Diesel exhaust particle-induced airway responses are augmented in obese rats.
复制标题
肥胖大鼠柴油排气颗粒引起的气道反应会增加。
DOI：
10.1177/1091581813518355
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发表时间：
2014-01
影响因子：
2.2
通讯作者：
Jang AS
中科院分区：
文献类型：
--
作者：
Moon KY;Park MK;Leikauf GD;Park CS;Jang AS
空气污染物和肥胖是导致哮喘的重要因素。本研究的目的是评估暴露于柴油机排气颗粒（DEPs）的大冢-朗伊文思德岛肥胖（OLETF）大鼠和朗伊文思德岛-大冢（LETO）非肥胖大鼠的气道反应性和炎症。将大冢Long Evans德岛肥胖大鼠和LETO大鼠鼻内暴露于DEP，然后在第6至8天用雾化DEP激发。进行身体体积描记术、支气管肺泡灌洗（BAL）和组织学检查。在第9天测量增强的停顿（Penh）作为气道阻力的指标，并在第10天收集样品。暴露于DEP后，OLETF组的Penh增加幅度大于LETO组。此外，与DEP暴露的LETO组相比，DEP暴露的OLETF组小鼠的BAL液显示总细胞计数和分类细胞计数增加。每组肺组织的组织学评估显示，DEP暴露的OLETF组倾向于在支气管前区域中具有增加的炎性细胞浸润。与非肥胖大鼠相比，暴露于DEP后，肥胖大鼠肺中过氧化物酶体增殖物激活受体γ，辅激活因子1β信使RNA增加。这些数据表明，与DEP暴露的LETO组相比，DEP暴露的OLETF组具有增加的气道反应和炎症，表明柴油颗粒和肥胖可能是哮喘的共同贡献者。
Air pollutants and obesity are important factors that contribute to asthma. The aim of this study was to assess the airway responsiveness and inflammation in Otsuka-Long Evans Tokushima Fatty (OLETF) obese rats and Long Evans Tokushima-Otsuka (LETO) nonobese rats exposed to diesel exhaust particles (DEPs). Otsuka Long Evans Tokushima fatty rats and LETO rats were exposed intranasally to DEP and then challenged with aerosolized DEP on days 6 to 8. Body plethysmography, bronchoalveolar lavage (BAL), and histology were performed. Enhanced pause (Penh) was measured as an indicator of airway resistance on day 9 and samples were collected on day 10. After exposure to DEP, the OLETF group exhibited a greater increase in Penh compared to that in the LETO group. Moreover, the BAL fluid in mice showed an increase in the total and differential cell counts in the DEP-exposed OLETF group compared to that in the DEP-exposed LETO group. Histological assessment of lung tissue from each group revealed that the DEP-exposed OLETF group tended to have increased inflammatory cell infiltrations in the prebronchial area. Increased peroxisome proliferator-activated receptor γ, coactivator 1β messenger RNA was observed in the lungs of obese rats compared to that in nonobese rats following DEP exposure. These data indicate that the DEP-exposed OLETF group had increased airway responses and inflammation compared to the DEP-exposed LETO group, indicating that diesel particulates and obesity may be co-contributors to asthma.
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影响因子：
120.7
作者：
Mokdad, AH;Serdula, MK;Koplan, JP
通讯作者：
Koplan, JP
影响因子：
4.5
作者：
Ichinose, T;Takano, H;Shibamoto, T
通讯作者：
Shibamoto, T
影响因子：
10
作者：
Chinn, S;Jarvis, D;Burney, P
通讯作者：
Burney, P
DOI：
10.1164/ajrccm.156.3.9606031
发表时间：
1997-09-01
影响因子：
24.7
作者：
Hamelmann, E;Schwarze, J;Gelfand, EW
通讯作者：
Gelfand, EW
影响因子：
4.4
作者：
Bleck, Bertram;Tse, Doris B.;Reibman, Joan
通讯作者：
Reibman, Joan