The influence of tumour-derived extracellular vesicles on local and distal metastatic dissemination.
The influence of tumour-derived extracellular vesicles on local and distal metastatic dissemination.
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DOI：
10.1016/j.mam.2017.11.012
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发表时间：
2018-04
影响因子：
10.6
通讯作者：
Peinado H
中科院分区：
文献类型：
--
作者：
Nogués L;Benito-Martin A;Hergueta-Redondo M;Peinado H
细胞外小泡(EVS)是细胞间通讯的关键媒介，但几十年来一直被忽视。肿瘤细胞受益于小泡的分泌，因为它们可以影响肿瘤微环境中邻近肿瘤细胞的行为。一些研究表明，细胞外小泡在转移前生态位的形成中起着积极的作用，重要的是，它们参与了不同类型肿瘤的转移器官趋向性。肿瘤衍生的电动汽车携带分子并将其转移到受体细胞，通过一种被称为“电动汽车驱动的教育”的过程来改变它们的行为。EV教育加强了一些有利于前哨淋巴结和远端器官转移的事件，包括血管生成、炎症和淋巴管生成。因此，在这篇综述中，我们将总结肿瘤来源的EV调节淋巴转移和远端器官转移的主要机制。此外，由于一些癌症通过淋巴系统转移，我们将讨论关于淋巴中肿瘤EVS的存在和功能的最新发现。最后，我们将讨论肿瘤EV作为液体活检，特别是血液和淋巴液的预后生物标记物的潜在价值，以及这些工具作为转移的早期检测器的使用。
Extracellular vesicles (EVs) are key mediators of intercellular communication that have been ignored for decades. Tumour cells benefit from the secretion of vesicles as they can influence the behaviour of neighbouring tumour cells within the tumour microenvironment. Several studies have shown that extracellular vesicles play an active role in pre-metastatic niche formation and importantly, they are involved in the metastatic organotropism of different tumour types. Tumour-derived EVs carry and transfer molecules to recipient cells, modifying their behaviour through a process known as “EV-driven education”. Several events that favour metastasis to sentinel lymph nodes and distal organs are reinforced by EV education, including angiogenesis, inflammation and lymphangiogenesis. Hence, in this review we will summarize the main mechanisms by which tumour-derived EVs regulate lymph node and distal organ metastasis. Moreover, since some cancers metastasize through the lymphatic system, we will discuss recent discoveries about the presence and function of tumour EVs in the lymph. Finally, we will address the potential value of tumour EVs as prognostic biomarkers in liquid biopsies, specially blood and lymphatic fluid, and the use of these tools as early detectors of metastases.
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影响因子：
3.7
作者：
Enderle D;Spiel A;Coticchia CM;Berghoff E;Mueller R;Schlumpberger M;Sprenger-Haussels M;Shaffer JM;Lader E;Skog J;Noerholm M
通讯作者：
Noerholm M
影响因子：
3.7
作者：
Benito-Martin A;Ucero AC;Zubiri I;Posada-Ayala M;Fernandez-Fernandez B;Cannata-Ortiz P;Sanchez-Nino MD;Ruiz-Ortega M;Egido J;Alvarez-Llamas G;Ortiz A
通讯作者：
Ortiz A
影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
影响因子：
0.7
作者：
De Wever, Olivier;Hendrix, An;Bracke, Marc
通讯作者：
Bracke, Marc
影响因子：
11.2
作者：
Dai, JL;Keller, J;Keller, ET
通讯作者：
Keller, ET