Deep brain stimulation of the lateral cerebellar nucleus produces frequency-specific alterations in motor evoked potentials in the rat in vivo.
Deep brain stimulation of the lateral cerebellar nucleus produces frequency-specific alterations in motor evoked potentials in the rat in vivo.
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DOI：
10.1016/j.expneurol.2010.08.019
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发表时间：
2010-12
影响因子：
5.3
通讯作者：
Machado, Andre G.
中科院分区：
文献类型：
--
作者：
Baker, Kenneth B.;Schuster, Daniel;Cooperrider, Jessica;Machado, Andre G.
关键词：
大脑皮质与小脑紧密相连，齿状-丘脑-皮质上行通路影响广泛的皮质区域。使用啮齿动物模型的大脑中动脉中风，我们以前表明，慢性，20 Hz刺激对侧小脑外侧核（LCN）改善运动恢复，而50 Hz的刺激没有。使用运动诱发电位（MEP）引起的皮层内微刺激，我们现在显示的影响，LCN刺激运动皮层兴奋性作为一个函数的脉冲频率在异丙酚麻醉大鼠。以15秒的间隔连续记录MEP，以20、30、40、50或100 Hz的频率在10分钟的时间段内给予小脑刺激。20、30、40或50 Hz的刺激增强了整个阻滞的平均MEP反应，在30 Hz刺激期间观察到最大的总体增加。然而，该效应随着在阻滞内的重复试验和LCN刺激频率而变化，使得40 Hz和50 Hz刺激显示出随时间降低的效应。在100 Hz的刺激在一些动物中产生MEP振幅的瞬时增加;然而，整个块的总体效果是朝向降低皮质兴奋性的趋势。这些结果表明，直接刺激LCN可以产生频率依赖性的变化，皮质兴奋性，并可能提供一种治疗方法来调节皮质活动的治疗中风或其他局灶性皮质病变，运动障碍和癫痫。
The cerebral cortex is tightly and reciprocally linked to the cerebellum and the ascending dentato-thalalmo-cortical pathway influences widespread cortical regions. Using a rodent model of middle cerebral artery stroke, we showed previously that chronic, 20 Hz stimulation of the contralateral lateral cerebellar nucleus (LCN) improved motor recovery, while 50 Hz stimulation did not. Using motor evoked potentials (MEP) elicited by intracortical microstimulation, we now show the effect of LCN stimulation on motor cortex excitability as a function of pulse frequency in propofol-anesthetized rats. MEPs were recorded serially, at 15-second intervals, with cerebellar stimulation delivered in 10-minute blocks at rates of 20, 30, 40, 50 or 100 Hz. Stimulation at 20, 30, 40 or 50 Hz enhanced the average MEP response across the block, with the maximal overall increase observed during 30 Hz stimulation. However, the effect varied as a function of both repeated trials within the block and LCN stimulation frequency, such that 40 Hz and 50 Hz stimulation showed a reduced effect over time. Stimulation at 100 Hz produced a transient increase in MEP amplitude in some animals; however the overall effect across the block was a trend towards reduced cortical excitability. These results suggest that direct stimulation of the LCN can yield frequency-dependent changes in cortical excitability and may provide a therapeutic approach to modulating cortical activity for the treatment of strokes or other focal cortical lesions, movement disorders and epilepsy.
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影响因子：
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作者：
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