Abstract and Effector-Selective Decision Signals Exhibit Qualitatively Distinct Dynamics before Delayed Perceptual Reports
Abstract and Effector-Selective Decision Signals Exhibit Qualitatively Distinct Dynamics before Delayed Perceptual Reports
复制标题
抽象和效应器选择性决策信号在延迟感知报告之前表现出定性独特的动态
作者：
Deirdre M. Twomey;S. Kelly;R. O’Connell
电生理学研究已经在不同的大脑区域分离出了决策形成的神经信号。对啮齿动物和猴子的研究主要集中在效应器选择性信号上，这些信号将新出现的决定转化为特定的运动计划，但最近，对人类大脑的研究发现了证据积累的抽象特征，似乎在行动准备中没有任何直接作用。这些不同的信号类型之间的功能解离才开始被表征，和他们的动态决策过程中的延迟行动与或不预先知道的刺激效应映射，一个常见的研究任务的情况下，在单单位和功能成像调查，尚未建立。在这里，我们追踪了不同的抽象和效应器选择性决策信号的动力学，分别以宽带中心顶叶阳性（CPP）和肢体选择性β波段（8-16和18-30 Hz）EEG活动的形式，在有和没有方向反应映射的预知的延迟报告的运动方向决策期间。在预知的情况下，CPP和β-带信号在证据出现后表现出类似的逐渐积累，但选择预测β-带活动持续到延迟反应，CPP在达到峰值后向基线下降。在没有预知的情况下，CPP表现出相同的动力学，而选择性β带活性被消除。这些发现突出了效应器选择性和抽象决策信号之间的定性功能差异，并与建立决策功能神经影像学研究的假设相关。证据积累的神经信号已经在许多大脑区域中被分离出来。虽然动物神经生理学主要集中在效应器选择性决策信号，将新兴的决定转化为特定的运动计划，但最近对人类大脑的研究已经分离出独立于特定感觉和运动要求的决策形成的抽象神经特征。在这里，我们研究了两个不同类别的决策变量信号之间的功能差异，在决策过程中，延迟的行动，没有预知的刺激效应映射。我们发现显着的区别，在人类大脑中的抽象与效应器选择性的决策信号的动态，通过响应延迟和应急的预知刺激-响应映射的维持。
Electrophysiological research has isolated neural signatures of decision formation in a variety of brain regions. Studies in rodents and monkeys have focused primarily on effector-selective signals that translate the emerging decision into a specific motor plan, but, more recently, research on the human brain has identified an abstract signature of evidence accumulation that does not appear to play any direct role in action preparation. The functional dissociations between these distinct signal types have only begun to be characterized, and their dynamics during decisions with deferred actions with or without foreknowledge of stimulus-effector mapping, a commonly studied task scenario in single-unit and functional imaging investigations, have not been established. Here we traced the dynamics of distinct abstract and effector-selective decision signals in the form of the broad-band centro-parietal positivity (CPP) and limb-selective β-band (8–16 and 18–30 Hz) EEG activity, respectively, during delayed-reported motion direction decisions with and without foreknowledge of direction-response mapping. With foreknowledge, the CPP and β-band signals exhibited a similar gradual build-up following evidence onset, but whereas choice-predictive β-band activity persisted up until the delayed response, the CPP dropped toward baseline after peaking. Without foreknowledge, the CPP exhibited identical dynamics, whereas choice-selective β-band activity was eliminated. These findings highlight qualitative functional distinctions between effector-selective and abstract decision signals and are of relevance to the assumptions founding functional neuroimaging investigations of decision-making. SIGNIFICANCE STATEMENT Neural signatures of evidence accumulation have been isolated in numerous brain regions. Although animal neurophysiology has largely concentrated on effector-selective decision signals that translate the emerging decision into a specific motor plan, recent research on the human brain has isolated abstract neural signatures of decision formation that are independent of specific sensory and motor requirements. Here, we examine the functional distinctions between the two distinct classes of decision variable signal during decisions with deferred actions with and without foreknowledge of stimulus-effector mapping. We find salient distinctions in the dynamics of abstract versus effector-selective decision signals in the human brain, in terms of sustainment through response delays and contingency on foreknowledge of stimulus–response mapping.
影响因子：
2.5
作者：
Shadlen, MN;Newsome, WT
通讯作者：
Newsome, WT
影响因子：
2.5
作者：
Kayser, Andrew S.;Buchsbaum, Bradley R.;D'Esposito, Mark
通讯作者：
D'Esposito, Mark