The Function of Thioredoxin-Binding Protein-2 (TBP-2) in Different Diseases.
The Function of Thioredoxin-Binding Protein-2 (TBP-2) in Different Diseases.
复制标题
硫氧还蛋白结合蛋白-2 (TBP-2) 在不同疾病中的功能
DOI：
10.1155/2018/4582130
复制
发表时间：
2018
影响因子：
--
通讯作者：
Yu Y
中科院分区：
文献类型：
--
作者：
Hu J;Yu Y
硫氧还蛋白结合蛋白-2（TBP-2）在氧化还原系统中具有重要作用，但它在许多不同的疾病中起不同的作用（例如，各种癌症、糖尿病（DM）、心血管疾病和白内障）通过影响细胞增殖、分化、细胞凋亡、自噬和代谢来治疗。受不同因子刺激的不同转录因子与结合位点或蛋白质联合收割机，上调或下调TBP-2的表达，以响应内环境的变化。多数研究表明TBP-2的主要功能是与硫氧还蛋白（Trx）结合，抑制Trx的抗氧化能力。此外，位于组织中的TBP-2，无论是正常的还是异常的，都具有通过不同途径引起细胞功能障碍甚至死亡的能力，例如缩短细胞周期和诱导凋亡或自噬。通过这些研究，我们发现TBP-2促进了与炎症和氧化损伤有关的疾病的发展。在一定程度上，我们认为TBP-2参与的生物学功能与一些独特的疾病之间存在着某种隐藏的联系。本文仅就TBP-2在肿瘤、糖尿病、白内障等疾病中的作用及其普遍机制作一综述。TBP-2的细胞信号转导通路需要进一步研究。更深入地了解TBP-2的机制可以产生潜在的治疗疾病的新靶点，包括癌症和糖尿病，心血管疾病和白内障。
Thioredoxin-binding protein-2 (TBP-2) has an important role in the redox system, but it plays a different role in many different diseases (e.g., various cancers, diabetes mellitus (DM), cardiovascular disease, and cataracts) by influencing cell proliferation, differentiation, apoptosis, autophagy, and metabolism. Distinct transcription factors (TFs) stimulated by different factors combine with binding sites or proteins to upregulate or downregulate TBP-2 expression, in order to respond to the change in the internal environment. Most research disclosed that the main function of TBP-2 is associating with thioredoxin (Trx) to inhibit the antioxidant capacity of Trx. Furthermore, the TBP-2 located in tissues, whether normal or abnormal, has the ability to cause the dysfunctioning of cells and even death through different pathways, such as shortening the cell cycle and inducing apoptosis or autophagy. Through these studies, we found that TBP-2 promoted the development of diseases which are involved in inflammatory and oxidative damage. To a certain extent, we believe that there is some hidden connection between the biological functions which TBP-2 participates in and some distinct diseases. This review presents only a summary of the roles that TBP-2 plays in cancer, DM, cataracts, and so on, as well as its universal mechanisms. Further investigations are needed for the cell signaling pathways of the effects caused by TBP-2. A greater understanding of the mechanisms of TBP-2 could produce potential new targets for the treatment of diseases, including cancer and diabetes, cardiovascular disease, and cataracts.
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影响因子：
11.2
作者：
Jeon, JH;Lee, KN;Choi, I
通讯作者：
Choi, I
DOI：
10.1016/j.bbrc.2004.01.047
发表时间：
2004-03-05
影响因子：
3.1
作者：
Kim, KY;Shin, SM;Choi, I
通讯作者：
Choi, I
影响因子：
3.5
作者：
Le Jan, Sébastien;Le Meur, Nolwenn;Germain, Stéphane
通讯作者：
Germain, Stéphane
影响因子：
8
作者：
Ahsan, MK;Masutani, H;Yodoi, J
通讯作者：
Yodoi, J
影响因子：
9
作者：
Devi TS;Somayajulu M;Kowluru RA;Singh LP
通讯作者：
Singh LP