Drug induced rhabdomyolysis.
Drug induced rhabdomyolysis.
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DOI：
10.1016/j.coph.2012.04.002
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发表时间：
2012-06
影响因子：
4
通讯作者：
Hohenegger, Martin
中科院分区：
文献类型：
--
作者：
Hohenegger, Martin
横纹肌溶解症由肌浆Ca 2+浓度升高和ATP减少引起。根据目前使用的实验室参数，无法预测横纹肌溶解症发作的发生。计算机模拟工具可能有助于阐明预防罕见横纹肌溶解症事件的新策略。横纹肌溶解症是由包括药物和毒素在内的多种机制引起的潜在危及生命的骨骼肌破坏的临床病症。考虑到结构上不相关的化合物导致相同的表型，确定了共同的靶点或途径，负责执行横纹肌溶解。肌浆ATP含量下降伴胞浆Ca 2+浓度持续升高是横纹肌溶解症的常见特征。有趣的是，心脏组织几乎不受影响或仅为继发性，这是电解质失衡或酸碱平衡的结果。这种教条现在被化合物削弱了，这些化合物在心脏和骨骼肌中表现出联合毒性。在这篇综述中，横纹肌溶解症的情况下，新的最近批准的药物将探索新的目标机制，在以前描述的病理机制。
► Rhabdomyolysis is paralleled by elevated myoplasmic Ca2+ concentrations and reduced ATP. ► The development of an episode of rhabdomyolysis cannot be predicted from currently used laboratory parameters. ► In silico tools might help to elucidate novel strategies to prevent the rare event of rhabdomyolysis. Rhabdomyolysis is a clinical condition of potential life threatening destruction of skeletal muscle caused by diverse mechanisms including drugs and toxins. Given the fact that structurally not related compounds cause an identical phenotype pinpoints to common targets or pathways, responsible for executing rhabdomyolysis. A drop in myoplasmic ATP paralleled with sustained elevations in cytosolic Ca2+ concentration represents a common signature of rhabdomyolysis. Interestingly, cardiac tissue is hardly affected or only secondary, as a consequence of imbalance in electrolytes or acid–base equilibrium. This dogma is now impaired by compounds, which show up with combined toxicity in heart and skeletal muscle. In this review, cases of rhabdomyolysis with novel recently approved drugs will be explored for new target mechanisms in the light of previously described pathomechanisms.
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DOI：
10.1007/s11626-010-9311-5
发表时间：
2010-07-01
影响因子：
2.1
作者：
Kostrominova, Tatiana Y.;Coleman, Scott;Larkin, Lisa M.
通讯作者：
Larkin, Lisa M.
影响因子：
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作者：
Motsch, J;Roggenbach, J
通讯作者：
Roggenbach, J
DOI：
10.1007/bf03013547
发表时间：
1999-06-01
期刊：
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
影响因子：
--
作者：
Obata, R;Yasumi, Y;Sato, S
通讯作者：
Sato, S
影响因子：
11.8
作者：
Papadopoulos, Stella;Ball, Amanda M.;Murphy, Brian S.
通讯作者：
Murphy, Brian S.
DOI：
10.1111/j.1752-8062.2008.00090.x
发表时间：
2009-02
期刊：
Clinical and translational science
影响因子：
--
作者：
Kerkela R;Woulfe KC;Durand JB;Vagnozzi R;Kramer D;Chu TF;Beahm C;Chen MH;Force T
通讯作者：
Force T