An Anatomically Constrained Model for Path Integration in the Bee Brain.
An Anatomically Constrained Model for Path Integration in the Bee Brain.
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DOI：
10.1016/j.cub.2017.08.052
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发表时间：
2017-10-23
期刊：
影响因子：
--
通讯作者：
Heinze S
中科院分区：
文献类型：
--
作者：
Stone T;Webb B;Adden A;Weddig NB;Honkanen A;Templin R;Wcislo W;Scimeca L;Warrant E;Heinze S
路径整合是一种广泛的导航策略，其中方向变化和所覆盖的距离在向外的旅程中不断整合，从而实现直线返回家园。蜜蜂使用视觉来完成这项任务--基于天体线索的视觉罗盘和基于光流的视觉里程计--但其潜在的神经整合机制尚不清楚。使用细胞内电生理学，我们表明，偏振光为基础的罗盘神经元和光流为基础的速度编码神经元收敛在蜜蜂大脑的中央复合体，并通过块面电子显微镜，我们确定潜在的积分细胞。基于这些细胞的合理输出目标，我们提出了一个完整的电路，在中央复合体中进行路径整合和转向，并为每个处理步骤提出了解剖学识别的神经元。由此产生的模型电路，从而完全生物约束，并提供了许多以前无法解释的中央复杂的建筑特征的功能解释。此外，我们发现，新发现的速度神经元的感受野可以支持路径整合的完整运动（即地面速度，不精确对齐与身体方向）典型的蜜蜂飞行，一个功能没有捕获在任何以前提出的模型的路径整合。在更广泛的背景下，提出的模型电路提供了一个通用的机制，通过比较当前和所需的航向产生转向信号-这表明一个更基本的功能，中央复杂的连接路径整合可能已经演变。
Path integration is a widespread navigational strategy in which directional changes and distance covered are continuously integrated on an outward journey, enabling a straight-line return to home. Bees use vision for this task – a celestial-cue based visual compass, and an optic-flow based visual odometer – but the underlying neural integration mechanisms are unknown. Using intracellular electrophysiology, we show that polarized-light based compass-neurons and optic-flow-based speed-encoding neurons converge in the central complex of the bee brain, and through block-face electron microscopy we identify potential integrator cells. Based on plausible output targets for these cells, we propose a complete circuit for path integration and steering in the central complex, with anatomically-identified neurons suggested for each processing step. The resulting model-circuit is thus fully constrained biologically and provides a functional interpretation for many previously unexplained architectural features of the central complex. Moreover, we show that the receptive fields of the newly discovered speed neurons can support path integration for the holonomic motion (i.e. a ground velocity that is not precisely aligned with body orientation) typical of bee-flight, a feature not captured in any previously proposed model of path integration. In a broader context, the model-circuit presented provides a general mechanism for producing steering signals by comparing current and desired headings – suggesting a more basic function for central-complex connectivity from which path integration may have evolved.
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