Innovations in Disease State Responsive Soft Materials for Targeting Extracellular Stimuli Associated with Cancer, Cardiovascular Disease, Diabetes, and Beyond.
Innovations in Disease State Responsive Soft Materials for Targeting Extracellular Stimuli Associated with Cancer, Cardiovascular Disease, Diabetes, and Beyond.
复制标题
DOI：
10.1002/adma.202007504
复制
发表时间：
2021-11
影响因子：
29.4
通讯作者：
Gianneschi, Nathan C.
中科院分区：
文献类型：
--
作者：
Battistella, Claudia;Liang, Yifei;Gianneschi, Nathan C.
关键词：
聚合物化学、材料科学和生物技术的最新进展使复杂的可编程纳米药物和材料的临床前开发成为可能，这些药物和材料能够精确地响应特定的疾病相关触发因素和微环境。这些内源性的刺激包括pH值、氧化还原状态、小分子和蛋白质的上调。在此，我们描述了可编程软材料的最新进展和创新方法，这些材料能够感知上述疾病相关的刺激，并通过一系列动态过程做出反应，包括形态和大小的转变、移动性和保留性的变化以及拆卸。在这个领域，大多数正在进行的和过去的研究工作都集中在肿瘤学上。鉴于这种兴趣，我们选择了癌症化疗和免疫治疗策略的最新创新方法的例子。此外，随着该领域的广泛关注，我们强调了可编程材料在其他疾病中的应用，特别关注心血管疾病和糖尿病，该领域的关注有限，但存在许多有前途的途径，具有很高的潜在影响。在过去的十年中，生物医学应用的可编程软材料领域迅速扩大。在此，我们描述了在治疗癌症、心血管疾病和糖尿病的临床前动物模型中显示出有希望的结果的最新进展。努力集中在能够感知与疾病相关的内源性刺激并通过一系列动态过程做出反应的材料上。
Recent advances in polymer chemistry, materials sciences, and biotechnology have allowed the preclinical development of sophisticated programmable nanomedicines and materials that are able to precisely respond to specific disease-associated triggers and microenvironments. These stimuli, endogenous to the targeted diseases, include pH, redox-state, small molecules and protein upregulation. Herein, we describe recent advances and innovative approaches in programmable soft materials capable of sensing the aforementioned disease associated stimuli and responding via a range of dynamic processes including morphological and size transitions, changes in mobility and retention, as well as disassembly. In this field generally, the majority of ongoing and past research effort has focused on oncology. Given this interest, we have chosen examples of the latest innovative approaches to chemo- and immunotherapy treatment strategies for cancer. Moreover, as the field broadens its attention, we highlight applications of programmable materials in other diseases, with a special focus on cardiovascular disease and diabetes mellitus, where limited attention has been paid by the field, but where many promising avenues exist with high potential impact. Over the past decade, the field of programmable soft materials for biomedical applications has rapidly expanded. Herein, we describe recent advances that show promising results in preclinical animal models for the treatment of cancer, cardiovascular disease and diabetes. Efforts have focused on materials capable of sensing the disease associated endogenous stimuli and responding via a range of dynamic processes.
登录
查看更多内容
影响因子：
29.4
作者：
Chien, Miao-Ping;Thompson, Matthew P.;Barback, Christopher V.;Ku, Ti-Hsuan;Hall, David J.;Gianneschi, Nathan C.
通讯作者：
Gianneschi, Nathan C.
影响因子：
29.4
作者：
Chen, Qian;Feng, Liangzhu;Liu, Zhuang
通讯作者：
Liu, Zhuang
影响因子：
16.6
作者：
Carlini, Andrea S.;Gaetani, Roberto;Gianneschi, Nathan C.
通讯作者：
Gianneschi, Nathan C.
DOI：
10.1073/pnas.1424684112
发表时间：
2015-02-24
影响因子：
11.1
作者：
Chou, Danny Hung-Chieh;Webber, Matthew J.;Anderson, Daniel G.
通讯作者：
Anderson, Daniel G.
影响因子：
15
作者：
Chien MP;Carlini AS;Hu D;Barback CV;Rush AM;Hall DJ;Orr G;Gianneschi NC
通讯作者：
Gianneschi NC