Risk Association of TOX3 and MMP7 Gene Polymorphisms with Sporadic Breast Cancer in Mexican Women.
Risk Association of TOX3 and MMP7 Gene Polymorphisms with Sporadic Breast Cancer in Mexican Women.
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DOI：
10.3390/curroncol29020086
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发表时间：
2022-02-11
期刊：
影响因子：
--
通讯作者：
Garza-Rodríguez ML
中科院分区：
文献类型：
--
作者：
Solis-Coronado O;Villarreal-Vela MP;Rodríguez-Gutiérrez HF;González-Guerrero JF;Cerda-Flores RM;Alcorta-Núñez F;Camarillo-Cárdenas KP;Pérez-Ibave DC;Vidal-Gutiérrez O;Ramírez-Correa GA;Garza-Rodríguez ML
乳腺癌（BC）是世界上发病率和死亡率最高的癌症之一。TOX 3 rs3803662和MMP 7 rs 1943779中的单核苷酸多态性（SNP）与BC易感性相关。在这项病例对照研究中，我们评估了rs3803662（TOX 3）/rs 1943779（MMP 7）SNP与墨西哥东北部妇女的临床特征、免疫组织化学反应性和BC风险相关性的关系。我们比较了212例BC病例和212例对照。从外周血中分离DNA进行聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析。我们计算了基因型频率、比值比和95%置信区间。我们发现CT（细胞色素-胸腺嘧啶）和TT（胸腺嘧啶-胸腺嘧啶）基因型以及TOX 3 rs3803662的T等位基因与BC风险相关（分别为p = 0.034，p = 0.011）。SNP TOX 3 rs3803662与阳性孕激素受体（PR）和三阴性BC（TNBC）相关，但与雌激素受体（ER）或HER 2反应性无关。SNP MMP 7 rs 1943779的CT和TT基因型（p = 0.006）和T等位基因（p = 0.002）与BC的风险相关。我们发现TOX 3 rs3803662和MMP 7 rs 1943779 SNP的T等位基因与BC风险相关。这些发现有助于墨西哥妇女的个性化医疗。
Breast cancer (BC) has one of the highest incidences and mortality worldwide. Single nucleotide polymorphisms (SNPs) in TOX3 rs3803662 and MMP7 rs1943779 have been associated with susceptibility to BC. In this case-control study, we evaluated the association of rs3803662 (TOX3)/rs1943779 (MMP7) SNPs with clinical features, immunohistochemical reactivity, and risk association with BC in women from northeastern Mexico. We compared 212 BC cases and 212 controls. DNA was isolated from peripheral blood to perform the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. We calculated genotype frequencies, odds ratios, and 95% confidence intervals. We found that CT (Cytocine–Thymine) and TT (Thymine –Thymine) genotypes, and T alleles of TOX3 rs3803662, were associated with BC risk (p = 0.034, p = 0.011, respectively). SNP TOX3 rs3803662 was associated with positive progesterone receptors (PR) and triple-negative BC (TNBC) but not with estrogen receptor (ER) or HER2 reactivity. CT and TT genotypes (p = 0.006) and T alleles (p = 0.002) of SNP MMP7 rs1943779 were associated with risk of BC. We found that T alleles of TOX3 rs3803662 and MMP7 rs1943779 SNPs are associated with BC risk. These findings contribute to personalized medicine in Mexican women.
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