Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy.
Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy.
复制标题
DOI：
10.3389/fonc.2022.1010411
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Guo, Yuexin
中科院分区：
文献类型：
--
作者：
Han, Bin;Wu, Bian;Hu, Fala;Ma, Yangguang;Wang, Haiyang;Han, Xinwei;Liu, Gang;Guo, Yuexin
本研究的目的是探讨肺癌立体定向放射治疗（SBRT）过程中分次内变异引起的靶剂量差异。调强放射治疗 (IMRT) 计划是基于平均计算机断层扫描 (AVG CT) 设计的，利用模型和患者病例中 65% 和 85% 处方等剂量周围的计划靶体积 (PTV)。通过将标称平面等中心点沿六个方向从 0.5 毫米移动到 4.5 毫米（步长为 1 毫米）来模拟变化，以产生一系列扰动平面。初始计划和扰动计划之间的剂量差异计算为初始计划的百分比。采用剂量指数，包括内部靶体积（ITV）和大体肿瘤体积（GTV）的ΔD99，作为终点样本。计算3维空间分布下的平均剂量差异。我们发现，运动会导致肺部 SBRT 中目标和 ITV 的严重剂量下降，尤其是在 PTV 围绕下等剂量线的 SBRT 期间。较低的等剂量线可能导致较大的剂量差异，同时使剂量下降梯度较陡。当考虑 3 维空间分布时，这种现象就受到了影响。该结果可为肺SBRT治疗过程中因运动引起的靶剂量降低提供前瞻性参考。
The purpose of this study was to investigate the target dose discrepancy caused by intrafraction variation during stereotactic body radiotherapy (SBRT) for lung cancer. Intensity-modulated radiation therapy (IMRT) plans were designed based on average computed tomography (AVG CT) utilizing the planning target volume (PTV) surrounding the 65% and 85% prescription isodoses in both phantom and patient cases. Variation was simulated by shifting the nominal plan isocenter along six directions from 0.5 mm to 4.5 mm with a 1-mm step size to produce a series of perturbed plans. The dose discrepancy between the initial plan and the perturbed plans was calculated as the percentage of the initial plan. Dose indices, including ΔD99 for internal target volume (ITV) and gross tumor volume (GTV), were adopted as endpoint samples. The mean dose discrepancy was calculated under the 3-dimensional space distribution. We found that motion can lead to serious dose degradation of the target and ITV in lung SBRT, especially during SBRT with PTV surrounding the lower isodose line. Lower isodose line may lead to larger dose discrepancy, while make steeper dose fall-off gradient. This phenomenon was compromised when 3-dimensional space distribution was considered. This result may provide a prospective reference for target dose degradation due to motion during lung SBRT treatment.
登录
查看更多内容
影响因子：
3.8
作者：
Glide-Hurst, Carri K.;Hugo, Geoffrey D.;Yan, Di
通讯作者：
Yan, Di
影响因子：
3.8
作者：
Lujan, AE;Larsen, EW;Ten Haken, RK
通讯作者：
Ten Haken, RK
影响因子：
2.1
作者：
Waghorn, Ben J.;Staton, Robert J.;Langen, Katja M.
通讯作者：
Langen, Katja M.
影响因子：
3.1
作者：
BLOMGREN, H;LAX, I;SVANSTROM, R
通讯作者：
SVANSTROM, R
影响因子：
20.4
作者：
Onishi, Hiroshi;Shirato, Hiroki;Araki, Tsutomu
通讯作者：
Araki, Tsutomu