Evaluation of Polymer-Coated Carbon Nanotube Flexible Microelectrodes for Biomedical Applications.
Evaluation of Polymer-Coated Carbon Nanotube Flexible Microelectrodes for Biomedical Applications.
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DOI：
10.3390/bioengineering10060647
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发表时间：
2023-05-26
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影响因子：
--
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生物医学应用中对电绝缘微线和微纤维的需求正在迅速增加。具有高电阻率、良好耐化学性和长保质期的聚合物保护涂层对于确保设备在长期应用过程中连续运行至关重要。由于柔软且灵活的电极可以最大限度地减少组织和电子设备之间的机械失配，因此人们提出了基于柔性导电微纤维（例如碳纳米管（CNT）纤维）和软聚合物绝缘材料的设计。在这项研究中，采用连续浸涂方法，用氢化丁腈橡胶（HNBR）（一种柔软的橡胶绝缘聚合物）对数米长的碳纳米管纤维进行绝缘。使用这种方法，直径为 25-66 µm 的 4.8 m 长的 CNT 纤维连续涂覆 HNBR，没有缺陷或中断。发现涂覆的碳纳米管纤维均匀、无针孔且具有生物相容性。此外，HNBR涂层比传统绝缘材料具有更好的耐高温性能。使用HNBR涂覆的CNT纤维制备的微电极表现出稳定的电化学性能，在1.0 kHz下的比阻抗为27.0 ± 9.4 MΩ µm2，阴极电荷存储容量为487.6 ± 49.8 mC cm−2。因此，所开发的电极表现出使其适合用于长期体内应用的植入式医疗设备的特性。
The demand for electrically insulated microwires and microfibers in biomedical applications is rapidly increasing. Polymer protective coatings with high electrical resistivity, good chemical resistance, and a long shelf-life are critical to ensure continuous device operation during chronic applications. As soft and flexible electrodes can minimize mechanical mismatch between tissues and electronics, designs based on flexible conductive microfibers, such as carbon nanotube (CNT) fibers, and soft polymer insulation have been proposed. In this study, a continuous dip-coating approach was adopted to insulate meters-long CNT fibers with hydrogenated nitrile butadiene rubber (HNBR), a soft and rubbery insulating polymer. Using this method, 4.8 m long CNT fibers with diameters of 25–66 µm were continuously coated with HNBR without defects or interruptions. The coated CNT fibers were found to be uniform, pinhole free, and biocompatible. Furthermore, the HNBR coating had better high-temperature tolerance than conventional insulating materials. Microelectrodes prepared using the HNBR-coated CNT fibers exhibited stable electrochemical properties, with a specific impedance of 27.0 ± 9.4 MΩ µm2 at 1.0 kHz and a cathodal charge storage capacity of 487.6 ± 49.8 mC cm−2. Thus, the developed electrodes express characteristics that made them suitable for use in implantable medical devices for chronic in vivo applications.
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影响因子：
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