Serum uric acid is associated with left ventricular hypertrophy independent of serum parathyroid hormone in male cardiac patients.
Serum uric acid is associated with left ventricular hypertrophy independent of serum parathyroid hormone in male cardiac patients.
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DOI：
10.1371/journal.pone.0082735
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Ishizaka N
中科院分区：
文献类型：
--
作者：
Fujita S;Okamoto Y;Shibata K;Morita H;Ito T;Sohmiya K;Hoshiga M;Ishizaka N
一些研究表明，血清尿酸（UA）与左心室（LV）肥大有关。血清甲状旁腺激素（PTH）水平已被证明与UA相关，也被认为与心脏肥大相关;然而，UA和心脏肥大之间的关系是否独立于PTH仍不清楚。我们研究了心脏病患者血清尿酸（UA）和左室肥厚之间的关系是否独立于完整的PTH和其他钙磷代谢相关因素。在一项回顾性研究中，在116例未服用降尿酸药物的男性心脏病患者（平均年龄65±12岁）中评估了UA与左心室质量指数之间的相关性。中位UA值为5.9 mg/dL。年龄和体重指数在UA四分位数组之间均无显著差异。UA水平较高的患者更可能服用袢利尿剂。UA与全段甲状旁腺素（PTH）呈显著相关（R = 0.34，P<0.001），与其他钙磷代谢相关因素无相关性。 线性回归分析显示，对数转换的UA与左心室质量指数显著相关，并且发现这种关系仅在未服用袢和/或噻嗪类利尿剂的患者中显著。多变量逻辑回归分析显示，对数转换的UA与LV肥大独立相关，比值比为2.79（95%置信区间1.48-5.28，每增加一个标准差，P=0.002）。 在心脏病患者中，血清UA与LV肥大相关，这种关系至少部分独立于完整的PTH水平，而在同一人群中，PTH水平与UA显著相关。
Several studies have shown that serum uric acid (UA) is associated with left ventricular (LV) hypertrophy. Serum levels of parathyroid hormone (PTH), which has bbe shown to be correlated with UA, is also known to be associated with cardiac hypertrophy; however, whether the association between UA and cardiac hypertrophy is independent of PTH remains unknown. We investigated whether the relationship between serum uric acid (UA) and LV hypertrophy is independent of intact PTH and other calcium-phosphate metabolism-related factors in cardiac patients. In a retrospective study, the association between UA and left ventricular mass index was assessed among 116 male cardiac patients (mean age 65±12 years) who were not taking UA lowering drugs. The median UA value was 5.9 mg/dL. Neither age nor body mass index differed significantly among the UA quartile groups. Patients with higher UA levels were more likely to be taking loop diuretics. UA showed a significant correlation with intact PTH (R = 0.34, P<0.001) but not with other calcium-phosphate metabolism-related factors. Linear regression analysis showed that log-transformed UA showed a significant association with left ventricular mass index, and this relationship was found to be significant exclusively in patients who were not taking loop and/or thiazide diuretics. Multivariate logistic regression analysis showed that log-transformed UA was independently associated with LV hypertrophy with an odds ratio of 2.79 (95% confidence interval 1.48–5.28, P = 0.002 per one standard deviation increase). Among cardiac patients, serum UA was associated with LV hypertrophy, and this relationship was, at least in part, independent of intact PTH levels, which showed a significant correlation with UA in the same population.
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DOI：
10.1152/ajpheart.01071.2010
发表时间：
2011-09-01
影响因子：
4.8
作者：
Chen, Chien-Chang;Hsu, Yu-Jung;Lee, Tsung-Ming
通讯作者：
Lee, Tsung-Ming
影响因子：
8.3
作者：
Iwashima, Y;Horio, T;Kawano, Y
通讯作者：
Kawano, Y
影响因子：
1.6
作者：
Liu, X.;Xie, R.;Liu, S.
通讯作者：
Liu, S.
甲状旁腺激素水平与高尿酸血症之间的独立关联：一项全国人口研究。
影响因子：
4.9
作者：
Hui JY;Choi JW;Mount DB;Zhu Y;Zhang Y;Choi HK
通讯作者：
Choi HK
影响因子：
39.3
作者：
Pilz, Stefan;Tomaschitz, Andreas;Maerz, Winfried
通讯作者：
Maerz, Winfried