The independent association between parathyroid hormone levels and hyperuricemia: a national population study.
The independent association between parathyroid hormone levels and hyperuricemia: a national population study.
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甲状旁腺激素水平与高尿酸血症之间的独立关联：一项全国人口研究。
DOI：
10.1186/ar3769
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发表时间：
2012-03-10
影响因子：
4.9
通讯作者：
Choi HK
中科院分区：
文献类型：
--
作者：
Hui JY;Choi JW;Mount DB;Zhu Y;Zhang Y;Choi HK
高尿酸血症和痛风发生率的增加与原发性甲状旁腺功能亢进有关，最近的甲状旁腺激素（PTH）临床试验报告了高尿酸血症不良事件。我们使用具有全国代表性的美国成年人样本评估了 PTH 对血清尿酸 (SUA) 水平的潜在人群影响。通过使用 2003 年至 2006 年全国健康和营养检查调查中 8,316 名 18 岁及以上参与者的数据，我们通过加权线性回归研究了血清 PTH 和 SUA 水平之间的关系。此外，我们通过加权逻辑回归研究了与高尿酸血症的关系。 SUA水平随着血清PTH浓度的增加而增加。调整年龄、性别、饮食因素、肾小球滤过率 (GFR) 和其他潜在相关生物标志物（钙、磷、碱性磷酸酶、25-羟基维生素 D）后，血清 PTH 水平从最低（参考）到最高五分位的 SUA 水平差异为 0、8、13、14 和 19 μM（95% CI，12 至 26；P 为趋势，< 0.001）。这些估计值在肾功能不全的个体中更大（PTH 极端五分位数之间的多变量 SUA 差异，GFR ≥ 60 和 < 60 ml/min 每 1.73 m2 的个体分别为 26 和 15 μM）（交互作用 P = 0.004）。各种定义的高尿酸血症的几率也随着 PTH 水平的增加而增加（趋势的多变量 P 值 < 0.05）。这些具有全国代表性的数据表明，血清 PTH 水平与人群水平的血清尿酸水平和高尿酸血症频率独立相关。
Increased frequencies of hyperuricemia and gout have been associated with primary hyperparathyroidism, and recent clinical trials of parathyroid hormone (PTH) have reported hyperuricemic adverse events. We evaluated the potential population impact of PTH on serum uric acid (SUA) levels by using a nationally representative sample of United States adults. By using data from 8,316 participants aged 18 years and older in the National Health and Nutrition Examination Survey 2003 to 2006, we examined the relation between serum PTH and SUA levels with weighted linear regression. Additionally, we examined the relation with hyperuricemia by using weighted logistic regression. SUA levels increased with increasing serum PTH concentration. After adjusting for age, sex, dietary factors, glomerular filtration rate (GFR), and other potentially related biomarkers (calcium, phosphorus, alkaline-phosphatase, 25-hydroxyvitamin D), the SUA level differences from the bottom (referent) to top quintiles of serum PTH levels were 0, 8, 13, 14, and 19 μM (95% CI, 12 to 26; P for trend, < 0.001). These estimates were larger among renally impaired individuals (multivariate SUA difference between the extreme quintiles of PTH, 26 versus 15 μM among those with GFR ≥ 60 versus < 60 ml/min per 1.73 m2, respectively) (P for interaction = 0.004). The odds of hyperuricemia by various definitions increased with increasing PTH levels as well (multivariate P values for trend, < 0.05). These nationally representative data indicate that serum PTH levels are independently associated with serum uric acid levels and the frequency of hyperuricemia at the population level.
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影响因子：
1.2
作者：
HISATOME, I;ISHIMURA, M;MASHIBA, H
通讯作者：
MASHIBA, H
影响因子：
15.9
作者：
So, Alexander;Thorens, Bernard
通讯作者：
Thorens, Bernard
影响因子：
158.5
作者：
MINTZ, DH;KYLE, LH;CANARY, JJ
通讯作者：
CANARY, JJ
影响因子：
4
作者：
Miller, P. D.;Schwartz, E. N.;Krege, J. H.
通讯作者：
Krege, J. H.
影响因子：
4.5
作者：
Kolz M;Johnson T;Sanna S;Teumer A;Vitart V;Perola M;Mangino M;Albrecht E;Wallace C;Farrall M;Johansson A;Nyholt DR;Aulchenko Y;Beckmann JS;Bergmann S;Bochud M;Brown M;Campbell H;EUROSPAN Consortium;Connell J;Dominiczak A;Homuth G;Lamina C;McCarthy MI;ENGAGE Consortium;Meitinger T;Mooser V;Munroe P;Nauck M;Peden J;Prokisch H;Salo P;Salomaa V;Samani NJ;Schlessinger D;Uda M;Völker U;Waeber G;Waterworth D;Wang-Sattler R;Wright AF;Adamski J;Whitfield JB;Gyllensten U;Wilson JF;Rudan I;Pramstaller P;Watkins H;PROCARDIS Consortium;Doering A;Wichmann HE;KORA Study;Spector TD;Peltonen L;Völzke H;Nagaraja R;Vollenweider P;Caulfield M;WTCCC;Illig T;Gieger C
通讯作者：
Gieger C