Streptococcus mutans-induced nephritis in rabbits.
Streptococcus mutans-induced nephritis in rabbits.
复制标题
变形链球菌引起的兔肾炎。
DOI：
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发表时间：
1985
影响因子：
6
通讯作者：
M. Stinson
中科院分区：
文献类型：
--
作者：
B. Albini;R. Nisengard;I. Glurich;M. Neiders;M. Stinson
经静脉给予破坏的变形链球菌至家兔超过23-76周，导致累及肾小球、肾小管和肾小球的严重肾炎。光镜下肾小球表现为弥漫性毛细血管内增生性肾小球肾炎，常伴有上皮新月体（65%）。电镜观察发现70%的肾脏标本肾小球中有驼峰。在一些家兔的肾小球中，广泛的纤维蛋白沉积和硬化是明显的。免疫荧光显示线性，颗粒状，通常是带状或斑片状免疫沉积物，包括C3，IgG，链球菌抗原，伊加和IgM，按频率递减的顺序。因此，在给予变形链球菌的家兔中观察到的肾炎的组织病理学和免疫组织学特征显示了人链球菌相关肾炎的许多特征，特别是在亚急性细菌性心内膜炎中遇到的弥漫性肾小球肾炎。此外，分析变形链球菌引起的肾炎可能对龋齿疫苗的评价和纯化产生影响。
Intravenous administration of disrupted Streptococcus mutans into rabbits over 23-76 weeks led to severe nephritis involving glomeruli, tubules, and interstitium. Light-microscopic observation of glomeruli documented diffuse endocapillary proliferative glomerulonephritis accompanied often (65%) by epithelial crescents. Electron-microscopic observation revealed humps in glomeruli of 70% of kidney specimens. In the glomeruli of some rabbits, extensive fibrin deposits and sclerosis were evident. Immunofluorescence showed linear, granular, often ribbonlike or patchy immune deposits encompassing, in order of decreasing frequency, C3, IgG, streptococcal antigen, IgA, and IgM. The histopathologic and immunohistologic features of the nephritis seen in rabbits given S mutans thus shows many features of Streptococcus-associated nephritides in man, in particular, the diffuse glomerular nephritis encountered in subacute bacterial endocarditis. Further, analysis of nephritis induced by administration of S mutans may have implications for the evaluation and purification of dental caries vaccines.
影响因子：
6.4
作者：
BEACHEY, EH
通讯作者：
BEACHEY, EH