The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies.
The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies.
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DOI：
10.1007/s12015-021-10230-x
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发表时间：
2021-12
影响因子：
4.8
通讯作者：
Zhang, Jiwang
中科院分区：
文献类型：
--
作者：
Mack, Ryan;Zhang, Lei;Breslin, Peter S. J.;Zhang, Jiwang
就像大多数器官系统在从胎儿到成人的过渡过程中经历不断的繁殖和成熟一样，造血和免疫系统也经历了动态变化。这些变化导致了儿童早期血液细胞功能和免疫反应的许多独特特征。新生儿的血细胞和免疫细胞是胎儿和成人来源的混合细胞，因为胎儿和成人类型的造血干细胞(HSCs)和祖细胞(HPC)共存。胎儿血液和免疫细胞在婴儿成熟过程中逐渐减少，在小鼠出生后3到4周几乎完全被成年型细胞取代。儿童早期的这些特征与这些发育阶段的造血和免疫疾病(如白血病)的独特特征有关。因此，了解发生在个体发育过程中的造血和免疫变化的细胞和分子机制将为儿科血液和免疫疾病的研究和治疗提供有用的信息。本文就胚胎发育早期的造血启动、胎肝和胎儿骨髓期胎儿和成人型造血干细胞和造血祖细胞的扩增以及新生儿/婴儿发育过程中从胎儿到成人的造血/免疫转移等方面的最新研究进展作一综述。我们还讨论了胎儿类型的HSCs/HPC在儿童白血病中的作用。
As with most organ systems that undergo continuous generation and maturation during the transition from fetal to adult life, the hematopoietic and immune systems also experience dynamic changes. Such changes lead to many unique features in blood cell function and immune responses in early childhood. The blood cells and immune cells in neonates are a mixture of fetal and adult origin due to the co-existence of both fetal and adult types of hematopoietic stem cells (HSCs) and progenitor cells (HPCs). Fetal blood and immune cells gradually diminish during maturation of the infant and are almost completely replaced by adult types of cells by 3 to 4 weeks after birth in mice. Such features in early childhood are associated with unique features of hematopoietic and immune diseases, such as leukemia, at these developmental stages. Therefore, understanding the cellular and molecular mechanisms by which hematopoietic and immune changes occur throughout ontogeny will provide useful information for the study and treatment of pediatric blood and immune diseases. In this review, we summarize the most recent studies on hematopoietic initiation during early embryonic development, the expansion of both fetal and adult types of HSCs and HPCs in the fetal liver and fetal bone marrow stages, and the shift from fetal-to-adult hematopoiesis/immunity during neonatal/infant development. We also discuss the contributions of fetal types of HSCs/HPCs to childhood leukemias.
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影响因子：
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作者：
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通讯作者：
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