Characteristics of young lung cancer: Analysis of Taiwan's nationwide lung cancer registry focusing on epidermal growth factor receptor mutation and smoking status.
Characteristics of young lung cancer: Analysis of Taiwan's nationwide lung cancer registry focusing on epidermal growth factor receptor mutation and smoking status.
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DOI：
10.18632/oncotarget.9338
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发表时间：
2016-07-19
期刊：
影响因子：
--
通讯作者：
Chang GC
中科院分区：
文献类型：
--
作者：
Hsu CH;Tseng CH;Chiang CJ;Hsu KH;Tseng JS;Chen KC;Wang CL;Chen CY;Yen SH;Chiu CH;Huang MS;Yu CJ;Tsai YH;Chen JS;Tsai CM;Chou TY;Lin KC;Tsai MH;Lee WC;Ku HY;Liu TW;Yang TY;Chang GC
肺癌在年轻患者中相对罕见，因为确诊时的中位年龄为65-70岁。这项全国性研究的主要目的是探讨台湾青年肺癌的特点，特别是吸烟行为、表皮生长因子受体(EGFR)突变与年龄的关系。这项研究分析了2011-2012年期间台湾国家肺癌登记处，这是一个包含详细癌症统计数据的数据库。青年肺癌定义为年龄≦为45岁。共有21,536名肺癌患者(13,187名男性和8349名女性)。在这些患者中，年轻组1074例(5.0%)，老年组20462例(95.0%)。女性(48.8%比38.2%，P<；0.001)、从不吸烟者(47.3%比43.8%，P=0.015)和腺癌(70.4%比58.1%，P<；0.001)在年轻组中更常见。年轻组的EGFR突变率较低(52.5%比60.6%，P=0.001)，但肺癌的原发部位和分期分布无明显差异。如果只将腺癌患者纳入分析，女性、年龄较大和从不吸烟的人更有可能发生EGFR突变。总而言之，年轻患者(≦，45岁)的肺癌与独特的特征有关，与老年患者相比，女性患者、腺癌和从不吸烟的患者比例更高，表皮生长因子受体突变率更低。
Lung cancer is relatively rare in young patients as the median age at diagnosis is 65–70 years. The main objective of this nationwide study was to investigate the characteristics of young lung cancer in Taiwan, especially the relationships among smoking behavior, epidermal growth factor receptor (EGFR) mutation, and age. The National Taiwan Lung Cancer Registry, a database contain detailed cancer statistics, was analyzed in this study for the period 2011–2012. Young lung cancer was defined as age ≦ 45 years. There were 21,536 lung cancer patients (13,187 men and 8349 women). Among these patients, 1074 (5.0%) were in the younger group, and 20,462 patients (95.0%) were in the older group. Female gender (48.8% versus 38.2%, P < 0.001), never-smokers (47.3% versus 43.8%, P = 0.015), and adenocarcinoma (70.4% versus 58.1%, P < 0.001) were more frequent in the younger group. While the EGFR mutation rate was lower in the younger group (52.5% versus 60.6%, P = 0.001), the primary site of lung cancer and stage distribution were not significantly different. If only adenocarcinoma patients were included in the analysis, female gender, older age, and never-smokers were more likely to have EGFR mutation. In conclusion, lung cancer in young patients (≦ 45 year-old) was associated with unique characteristics, with greater percentages of female patients, adenocarcinoma, and never-smokers and a lower EGFR mutation rate compared with older patients.
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