Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors.
Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors.
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DOI：
10.1186/1471-2407-12-241
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发表时间：
2012-06-13
期刊：
影响因子：
3.8
通讯作者：
Yang PC
中科院分区：
文献类型：
--
作者：
Hsu CL;Chen KY;Shih JY;Ho CC;Yang CH;Yu CJ;Yang PC
肺癌在年轻患者（小于或等于45岁）中并不常见，其临床特征与老年患者不同。我们研究了晚期非小细胞肺癌（NSCLC）年轻患者的预后和预后因素。从2000年1月到2009年12月，我们招募了年龄≤45岁，诊断为IIIB或IV期NSCLC的患者。我们回顾并分析了患者的临床资料，包括年龄、性别、体能状况、组织学类型、疾病分期、诊断时的实验室数据、治疗方式和生存期。采用Cox比例风险模型计算风险比（HR）及其95%置信区间（CI）。共纳入144例晚期NSCLC患者。女性患者较多（n = 74, 51.4%）。腺癌是两种性别中最常见的组织学类型（n = 119, 82.6%）（男性54,77.1%；女性65,87.8%）。使用来自58例患者的肿瘤标本测定表皮生长因子受体（EGFR）序列，其中29例显示EGFR突变。在有和没有EGFR突变的患者组之间，中位生存期无显著差异（798天对708天，p = 0.65）。在多变量分析中，男性（HR, 1.70; 95% CI: 1.08-2.68）、体重指数（BMI）小于25 kg/m2 （HR, 2.72; 95% CI: 1.39-5.30）、IV期疾病（HR, 2.62; 95% CI: 1.50-4.57）和贫血（HR, 2.08; 95% CI: 1.15-3.77）与生存时间短相关。低BMI、IV期疾病、诊断时贫血和男性是晚期NSCLC年轻患者的负面预后因素。
Lung cancer in young patients (less or equal to 45 years) is uncommon and has clinical characteristics different from that in older patients. We investigated the outcomes and prognostic factors of young patients with advanced non-small cell lung cancer (NSCLC). From January 2000 to December 2009, we enrolled patients aged ≤45 years and diagnosed with stage IIIB or IV NSCLC. Their clinical data, including age, gender, performance status, histologic types, disease stages, laboratory data at diagnosis, treatment modalities, and survival were reviewed and analyzed. A Cox proportional hazard model was used to calculate the hazard ratio (HR) and its 95% confidence interval (CI). A total of 144 patients with advanced NSCLC were included. Female patients were more prevalent (n = 74, 51.4%). Adenocarcinoma was the most common histologic type (n = 119, 82.6%) in both genders (male, n = 54, 77.1%; female, n = 65, 87.8%). Epidermal growth factor receptor (EGFR) sequences were determined using tumor specimens from 58 patients, and 29 showed an EGFR mutation. No significant difference in median survival was found between patient groups with and without the EGFR mutation (798 vs. 708 days, p = 0.65). In multivariate analysis, male gender (HR, 1.70; 95% CI: 1.08-2.68), body mass index (BMI) less than 25 kg/m2 (HR, 2.72; 95% CI: 1.39-5.30), stage IV disease (HR, 2.62; 95% CI: 1.50-4.57), and anemia (HR, 2.08; 95% CI: 1.15-3.77) were associated with a short survival time. Low BMI, stage IV disease, anemia at diagnosis, and male gender were the negative prognostic factors for young patients with advanced NSCLC.
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影响因子：
8.8
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