Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction.
Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction.
复制标题
DOI：
10.1016/j.xpro.2021.100775
复制
发表时间：
2021-09-17
期刊：
影响因子：
--
通讯作者：
Miyagawa-Tomita S
中科院分区：
文献类型：
--
作者：
Maruyama K;Naemura K;Yoshihara K;Imanaka-Yoshida K;Kurihara H;Miyagawa-Tomita S
心肌梗死（MI）是全球最常见的死亡原因之一。MI的动物模型对于研究病理生理学和开发治疗是有用的。在这里，我们描述了一种手术方案，永久结扎左冠状动脉前降支的小鼠，模仿人类急性冠状动脉综合征。该协议包括描述性的分步手术程序和高质量的手术视频，这对于执行稳定和高度可重复的手术非常有用。有关本方案使用和执行的完整详细信息，请参考永久性LAD结扎是产生小鼠MI模型的有效方法小鼠MI模型对于理解人类MI的病理生理学是有用的该方案包括高质量的手术视频以理解程序该方案对于在小鼠中执行稳定和可再现的MI模型是有用的心肌梗死（MI）是全世界最常见的死亡原因之一。MI的动物模型对于研究病理生理学和开发治疗是有用的。在这里，我们描述了一种手术方案，永久结扎左冠状动脉前降支的小鼠，模仿人类急性冠状动脉综合征。该协议包括描述性的分步手术程序和高质量的手术视频，这对于执行稳定和高度可重复的手术非常有用。
Myocardial infarction (MI) is one of the most common causes of death worldwide. Animal models for MI are useful for studying the pathophysiology and developing therapies. Here, we describe a surgical protocol for permanent ligation of the left anterior descending coronary artery in mice, which mimics human acute coronary syndrome. This protocol includes descriptive step-by-step surgical procedures and high-quality surgical videos, which are useful for performing stable and highly reproducible operations. For complete details on the use and execution of this protocol, please refer to Permanent LAD ligation is an effective approach to generate a mice MI model Mice MI models are useful for understanding the pathophysiology of human MI This protocol includes high-quality surgical videos to understand the procedures This protocol is useful for performing stable and reproducible MI models in mice Myocardial infarction (MI) is one of the most common causes of death worldwide. Animal models for MI are useful for studying the pathophysiology and developing therapies. Here, we describe a surgical protocol for permanent ligation of the left anterior descending coronary artery in mice, which mimics human acute coronary syndrome. This protocol includes descriptive step-by-step surgical procedures and high-quality surgical videos, which are useful for performing stable and highly reproducible operations.
影响因子：
5.8
作者：
Maruyama K;Naemura K;Arima Y;Uchijima Y;Nagao H;Yoshihara K;Singh MK;Uemura A;Matsuzaki F;Yoshida Y;Kurihara Y;Miyagawa-Tomita S;Kurihara H
通讯作者：
Kurihara H