Optimized Configuration of Functional Brain Network for Processing Semantic Audiovisual Stimuli Underlying the Modulation of Attention: A Graph-Based Study
Optimized Configuration of Functional Brain Network for Processing Semantic Audiovisual Stimuli Underlying the Modulation of Attention: A Graph-Based Study
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用于处理注意力调节下的语义视听刺激的功能脑网络的优化配置：基于图的研究
DOI：
10.3389/fnint.2019.00067
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发表时间：
2019-11
影响因子：
3.5
通讯作者：
Wu Jinglong
中科院分区：
文献类型：
--
作者：
Xi Yang;Li Qi;Zhang Mengchao;Liu Lin;Li Guangjian;Lin Weihong;Wu Jinglong
语义视听刺激对行为表现有促进作用，并影响跨感官形式的多感官输入的整合。许多神经影像学和电生理学研究探讨了多感觉语义加工的神经机制，并报道注意调节对多感觉语义输入的反应。本研究设计了一个功能磁共振成像（fMRI）实验，利用含有语义信息的单模态听觉、单模态视觉和双模态视听刺激进行语义辨别。通过对被试在注意和不注意位置上出现的刺激进行操作，记录了注意和不注意条件下对应于单模态听觉、单模态视觉和双模态视听刺激的任务相关fMRI数据。我们还记录了静息状态下的fMRI数据。然后利用fMRI方法结合图论分析，构建了任务相关和静息状态下的脑功能网络，并对网络拓扑性质进行了定量表征。本研究的目的是探讨在注意和非注意条件下，语义视听刺激的脑功能网络的特点，揭示多感觉加工和注意调节的神经机制。行为学结果表明，同时呈现的视听刺激促进了语义辨别任务的完成。对网络性质的分析表明，与静息状态相比，视听刺激加工的功能网络具有更强的小世界性和全局有效性，以及更低的聚类系数、特征路径长度、全局有效性和层次性。此外，枢纽集中在双侧颞叶，特别是前颞叶（ATLs），这与反应时（RT）呈正相关。此外，注意显著改变了小世界性的程度和枢纽的分布在功能网络处理语义视听刺激。我们的研究结果表明，语义视听刺激加工的脑功能网络拓扑结构受到注意的调节，具有高效率和低布线成本的特点，从而维持了多感觉加工的功能分离和整合之间的最佳平衡。
Semantic audiovisual stimuli have a facilitatory effect on behavioral performance and influence the integration of multisensory inputs across sensory modalities. Many neuroimaging and electrophysiological studies investigated the neural mechanisms of multisensory semantic processing and reported that attention modulates the response to multisensory semantic inputs. In the present study, we designed an functional magnetic resonance imaging (fMRI) experiment of semantic discrimination using the unimodal auditory, unimodal visual and bimodal audiovisual stimuli with semantic information. By manipulating the stimuli present on attended and unattended position, we recorded the task-related fMRI data corresponding to the unimodal auditory, unimodal visual and bimodal audiovisual stimuli in attended and unattended conditions. We also recorded the fMRI data in resting state. Then the fMRI method was used together with a graph theoretical analysis to construct the functional brain networks in task-related and resting states and quantitatively characterize the topological network properties. The aim of our present study is to explore the characteristics of functional brain networks that process semantic audiovisual stimuli in attended and unattended conditions, revealing the neural mechanism of multisensory processing and the modulation of attention. The behavioral results showed that the audiovisual stimulus presented simultaneously promoted the performance of semantic discrimination task. And the analyses of network properties showed that compared with the resting-state condition, the functional networks of processing semantic audiovisual stimuli (both in attended and unattended conditions) had greater small-worldness, global efficiency, and lower clustering coefficient, characteristic path length, global efficiency and hierarchy. In addition, the hubs were concentrated in the bilateral temporal lobes, especially in the anterior temporal lobes (ATLs), which were positively correlated to reaction time (RT). Moreover, attention significantly altered the degree of small-worldness and the distribution of hubs in the functional network for processing semantic audiovisual stimuli. Our findings suggest that the topological structure of the functional brain network for processing semantic audiovisual stimulus is modulated by attention, and has the characteristics of high efficiency and low wiring cost, which maintains an optimized balance between functional segregation and integration for multisensory processing efficiently.
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DOI：
10.1177/1073858416667720
发表时间：
2017-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bassett DS;Bullmore ET
通讯作者：
Bullmore ET
影响因子：
5.7
作者：
Congdon, Eliza;Mumford, Jeanette A.;Cohen, Jessica R.;Galvan, Adriana;Aron, Adam R.;Xue, Gui;Miller, Eric;Poldrack, Russell A.
通讯作者：
Poldrack, Russell A.
DOI：
10.1098/rstb.2012.0392
发表时间：
2014
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Lambon Ralph MA
通讯作者：
Lambon Ralph MA
DOI：
10.1093/cercor/bhv003
发表时间：
2015-11
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Jackson RL;Hoffman P;Pobric G;Lambon Ralph MA
通讯作者：
Lambon Ralph MA
影响因子：
19.9
作者：
Talsma, Durk;Senkowski, Daniel;Soto-Faraco, Salvador;Woldorff, Marty G.
通讯作者：
Woldorff, Marty G.