Inverse associations of total and decaffeinated coffee with liver enzyme levels in National Health and Nutrition Examination Survey 1999-2010.
Inverse associations of total and decaffeinated coffee with liver enzyme levels in National Health and Nutrition Examination Survey 1999-2010.
复制标题
DOI：
10.1002/hep.27367
复制
发表时间：
2014-12
期刊：
影响因子：
13.5
通讯作者：
Freedman, Neal D.
中科院分区：
文献类型：
--
作者：
Xiao, Qian;Sinha, Rashmi;Graubard, Barry I.;Freedman, Neal D.
咖啡可能具有保护肝脏的作用，而较高的咖啡摄入量与肝酶标记物水平呈负相关。然而，目前还不清楚无咖啡因咖啡是否也与肝酶有关。研究人群包括27,793名年龄在20岁或以上的美国国家健康和营养检查调查(1999-2010)的参与者。咖啡摄入量通过24小时饮食回忆来评估。测定血清丙氨酸氨基转移酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)和谷氨酰转氨酶(GGT)水平。我们使用加权多变量Logistic(酶异常升高)和线性回归(连续酶水平)来检验咖啡摄入量和酶水平之间的关系。咖啡的总摄入量与所有四种肝酶的异常水平以及AST、ALP和GGT的持续水平呈负相关。与那些报告每天不喝咖啡的参与者相比，报告每天喝3杯≥的参与者ALT、AST、ALP和GGT水平异常的优势比(OR)(95%可信区间)分别为0.75(0.63，0.89)、0.82(0.68，0.98)、0.73(0.55，0.95)和0.69(0.57，0.83)。无咖啡因咖啡摄入量与ALT(OR AST2vs0杯/d：0.62(0.41，0.94))、≥(0.74(0.49，1.11))和谷草转氨酶(0.70，0.49-1.00)水平异常之间也存在类似的负相关关系。摄入较多的咖啡，无论其咖啡因含量如何，都与较低的肝酶水平有关。
Coffee may have hepatoprotective effects and higher coffee consumption has been associated inversely with levels of liver enzymatic markers. However, it is unclear whether decaffeinated coffee is also associated with liver enzymes. The study population included 27,793 participants, age 20 or older, in the US National Health and Nutrition Examination Survey (1999–2010). Coffee intake was evaluated by 24-hour dietary recall. Serum levels of aminotransferase (ALT), aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transaminase (GGT) were measured. We examined the relationship between coffee intake and enzymatic levels using weighted multiple variable logistic (abnormally elevated levels of enzymes) and linear regression (continuous enzymatic levels). Total coffee consumption was inversely associated with abnormal levels of all four liver enzymes and continuous levels of AST, ALP and GGT. Compared to those reporting no coffee consumption, participants reporting ≥3 cups per day had an odds ratio (OR) (95% confidence interval (CI)) of 0.75 (0.63, 0.89)), 0.82 (0.68, 0.98), 0.73 (0.55, 0.95) and 0.69 (0.57, 0.83) for abnormal levels of ALT, AST, ALP and GGT, respectively. Similar inverse associations were found with decaffeinated coffee intake and abnormal levels of ALT (OR≥2 vs 0 cup/d: 0.62 (0.41, 0.94)), AST (0.74 (0.49, 1.11)), and GGT (0.70, 0.49–1.00). Higher intakes of coffee, regardless of its caffeine content, were associated with lower levels of liver enzymes.
登录
查看更多内容
影响因子：
1.8
作者：
Chiappini F
通讯作者：
Chiappini F
影响因子：
11.2
作者：
Hoshida Y;Nijman SM;Kobayashi M;Chan JA;Brunet JP;Chiang DY;Villanueva A;Newell P;Ikeda K;Hashimoto M;Watanabe G;Gabriel S;Friedman SL;Kumada H;Llovet JM;Golub TR
通讯作者：
Golub TR
影响因子：
13.5
作者：
Kaimori, Aki;Potter, James J.;Koteish, Ayman A.
通讯作者：
Koteish, Ayman A.
DOI：
10.1007/978-1-62703-321-3_25
发表时间：
2013-01-01
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Laurent, Veronique;Glaise, Denise;Loyer, Pascal
通讯作者：
Loyer, Pascal
肝脏中的肝细胞粘液细胞串扰会产生一种宽松的炎症微环境，可在肝细胞癌中进展。
影响因子：
11.2
作者：
Coulouarn C;Corlu A;Glaise D;Guénon I;Thorgeirsson SS;Clément B
通讯作者：
Clément B