Skin neurogenic inflammation.
Skin neurogenic inflammation.
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DOI：
10.1007/s00281-018-0675-z
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发表时间：
2018-05
影响因子：
9
通讯作者：
Di Nardo A
中科院分区：
文献类型：
--
作者：
Choi JE;Di Nardo A
表皮与神经末梢密切相互作用，表皮和神经产生相互支持的物质。神经肽，如SP和CGRP，由真皮中的感觉神经产生，它们诱导肥大细胞释放血管活性胺，促进中性粒细胞和T细胞的浸润。有些受体在瘙痒的产生中比其他受体更重要。MrP 1家族和TRPA 1、Par-2在瘙痒和炎症中起重要作用。MrgprX 1的激活使肥大细胞与感觉神经和皮肤细胞通讯，以发展神经源性炎症。Mrrna和TRPV 4对红斑痤疮等皮肤病的产生至关重要，而SP，CGRP，生长抑素，b-内啡肽，VIP和PACAP可以在银屑病发展过程中调节免疫系统。在特应性皮炎中，SP水平的增加诱导外周血单核白细胞释放IFN-γ、IL-4、TNF-α和IL-10。我们终于开始了解皮肤神经元和常驻皮肤细胞之间的复杂联系，以及它们的相互作用如何成为控制炎症的关键，并从那里了解特应性皮炎，牛皮癣和酒渣鼻等疾病的发病机制。
The epidermis closely interacts with nerve endings and both epidermidis and nerves, produce substances for mutual sustenance. Neuropeptides, like SP and CGRP, are produced by sensory nerves in the dermis, they induce mast cells to release vasoactive amines that facilitate infiltration of neutrophils and T cells. Some receptors are more important than other in the generation of itch. Mrgprs family and the TRPA1 and Par-2 have important roles in itch and inflammation. The activation of MrgprX1 degranulate mast cells to communicate with sensory nerve and cutaneous cells for developing neurogenic inflammation. Mrgprs and TRPV4 are crucial for the generation of skin diseases like Rosacea, while SP, CGRP, somatostatin, b-endorphin, VIP and PACAP, can modulate the immune system during psoriasis development. The increased level of SP, in atopic dermatitis, induces the release of IFN g, IL-4, TNF-a and IL-10 from the peripheral blood mononuclear leukocytes. We are finally starting to understand the intricate connections between the skin neurons and resident skin cells and how their interaction can be the key to control inflammation and from there the pathogenesis of diseases like atopic dermatitis, psoriasis and rosacea.
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DOI：
10.1084/jem.20082242
发表时间：
2009-05-11
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Briot A;Deraison C;Lacroix M;Bonnart C;Robin A;Besson C;Dubus P;Hovnanian A
通讯作者：
Hovnanian A
影响因子：
6.4
作者：
Beresford, L;Orange, O;Miyan, JA
通讯作者：
Miyan, JA
影响因子：
6.5
作者：
Burbach, GJ;Kim, KH;Armstrong, CA
通讯作者：
Armstrong, CA
影响因子：
15.9
作者：
Dai, Yi;Wang, Shenglan;Noguchi, Koichi
通讯作者：
Noguchi, Koichi
影响因子：
2.8
作者：
Bae, SJ;Matsunaga, Y;Katayama, I
通讯作者：
Katayama, I