Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair.
Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair.
复制标题
缺血性大脑和外周免疫系统之间的分子对话：损伤和修复中的双重作用
DOI：
10.1016/j.pneurobio.2013.12.002
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发表时间：
2014-04
影响因子：
6.7
通讯作者：
Chen, Jun
中科院分区：
文献类型：
--
作者：
An, Chengrui;Shi, Yeije;Li, Peiying;Hu, Xiaoming;Gan, Yu;Stetler, Ruth A.;Leak, Rehana K.;Gao, Yanqin;Sun, Bao-Liang;Zheng, Ping;Chen, Jun
免疫和炎症反应积极调节急性脑损伤的病理生理过程，如中风。中风发作后不久，脑源性抗原、危险相关分子模式（DAMPs）、细胞因子和趋化因子等信号从受伤的大脑释放到体循环中。受伤的大脑还通过自主神经系统的副交感神经和交感神经分支与周围器官交流。许多这些不同的信号不仅激活了大脑中的常驻免疫细胞，而且还引发了外周细胞的强烈免疫反应。然后外周免疫细胞向损伤部位迁移，并释放额外的细胞因子、趋化因子和其他分子，在缺血脑中造成进一步的破坏或保护作用。受伤的大脑和外周免疫系统之间的双向交流现在被认为可以调节中风病理的进展以及组织修复。最终，这种巧妙协调的相声帮助决定了中风后动物的命运。本文综述了通过缺血脑源性信号触发外周免疫反应的文献，以及这些外周反应对脑损伤和修复的潜在影响。以大脑和外周免疫系统之间的对话为目标的药理学策略和基于细胞的疗法有望成为中风的潜在新疗法。
Immune and inflammatory responses actively modulate the pathophysiological processes of acute brain injuries such as stroke. Soon after the onset of stroke, signals such as brain-derived antigens, danger-associated molecular patterns (DAMPs), cytokines, and chemokines are released from the injured brain into the systemic circulation. The injured brain also communicates with peripheral organs through the parasympathetic and sympathetic branches of the autonomic nervous system. Many of these diverse signals not only activate resident immune cells in the brain, but also trigger robust immune responses in the periphery. Peripheral immune cells then migrate toward the site of injury and release additional cytokines, chemokines, and other molecules, causing further disruptive or protective effects in the ischemic brain. Bidirectional communication between the injured brain and the peripheral immune system is now known to regulate the progression of stroke pathology as well as tissue repair. In the end, this exquisitely coordinated crosstalk helps determine the fate of animals after stroke. This article reviews the literature on ischemic brain-derived signals through which peripheral immune responses are triggered, and the potential impact of these peripheral responses on brain injury and repair. Pharmacological strategies and cell-based therapies that target the dialogue between the brain and peripheral immune system show promise as potential novel treatments for stroke.
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影响因子：
37.8
作者：
Caso, Javier R.;Pradillo, Jesus M.;Lizasoain, Ignacio
通讯作者：
Lizasoain, Ignacio
影响因子：
16.8
作者：
Appay, V;Rowland-Jones, SL
通讯作者：
Rowland-Jones, SL
DOI：
10.1073/pnas.0803945105
发表时间：
2008-11-25
影响因子：
11.1
作者：
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影响因子：
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作者：
Boutin, H;LeFeuvre, RA;Rothwell, NJ
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影响因子：
1.1
作者：
Bune, Laurids T.;Thaning, Pia;Rosenmeier, Jaya B.
通讯作者：
Rosenmeier, Jaya B.