Opioid-induced rewards, locomotion, and dopamine activation: A proposed model for control by mesopontine and rostromedial tegmental neurons.
Opioid-induced rewards, locomotion, and dopamine activation: A proposed model for control by mesopontine and rostromedial tegmental neurons.
复制标题
DOI：
10.1016/j.neubiorev.2017.09.022
复制
发表时间：
2017-12
影响因子：
8.2
通讯作者：
Yeomans JS
中科院分区：
文献类型：
--
作者：
Steidl S;Wasserman DI;Blaha CD;Yeomans JS
阿片类药物，如吗啡或海洛因，增加前脑多巴胺（DA）的释放和运动，并支持条件性位置偏爱（CPP）的获得或自我管理。在啮齿类动物中，这些阿片类药物作用最敏感的部位是腹侧被盖区（VTA）和头内侧被盖核（RMTg）。在这些网站的GABA神经元的阿片样物质的抑制被假设为通过腹侧被盖区DA神经元的去抑制，导致唤醒和奖励的效果。我们回顾的研究结果，背侧被盖（LDTg）和pedunculopontine被盖（PPTg）核，其中每一个都含有胆碱能，GABA能，神经元能细胞，这些影响是很重要的。LDTg和/或PPTg胆碱能输入VTA介导阿片类药物诱导的运动和DA激活通过VTA M5毒蕈碱受体。LDTg和/或PPTg胆碱能输入RMTg也调节阿片类药物诱导的运动。LDTg或PPTg神经元的损伤或抑制减少吗啡诱导的前脑DA释放增加，获得吗啡CPP或自我管理。我们提出了一个电路模型，连接腹侧被盖区和RMTg GABA与LDTg和PPTg神经元的DA依赖性阿片类药物的作用在药物初治啮齿动物的关键。
Opioids, such as morphine or heroin, increase forebrain dopamine (DA) release and locomotion, and support the acquisition of conditioned place preference (CPP) or self-administration. The most sensitive sites for these opioid effects in rodents are in the ventral tegmental area (VTA) and rostromedial tegmental nucleus (RMTg). Opioid inhibition of GABA neurons in these sites is hypothesized to lead to arousing and rewarding effects through disinhibition of VTA DA neurons. We review findings that the laterodorsal tegmental (LDTg) and pedunculopontine tegmental (PPTg) nuclei, which each contain cholinergic, GABAergic, and glutamatergic cells, are important for these effects. LDTg and/or PPTg cholinergic inputs to VTA mediate opioid-induced locomotion and DA activation via VTA M5 muscarinic receptors. LDTg and/or PPTg cholinergic inputs to RMTg also modulate opioid-induced locomotion. Lesions or inhibition of LDTg or PPTg neurons reduce morphine-induced increases in forebrain DA release, acquisition of morphine CPP or self-administration. We propose a circuit model that links VTA and RMTg GABA with LDTg and PPTg neurons critical for DA-dependent opioid effects in drug-naïve rodents.
登录
查看更多内容
影响因子：
3.7
作者：
Bajic D;Soiza-Reilly M;Spalding AL;Berde CB;Commons KG
通讯作者：
Commons KG
影响因子：
5.3
作者：
Borgland, SL;Malenka, RC;Bonci, A
通讯作者：
Bonci, A
影响因子：
4.7
作者：
Clark, S. D.;Alderson, H. L.;Civelli, O.
通讯作者：
Civelli, O.
影响因子：
3.6
作者：
BECHARA, A;VANDERKOOY, D
通讯作者：
VANDERKOOY, D
影响因子：
6.1
作者：
BOZARTH, MA;WISE, RA
通讯作者：
WISE, RA