Concentrations of HMGB1 and Hsp70 of healthy subjects in upper and lower airway: Literature Review and Meta-analysis.
Concentrations of HMGB1 and Hsp70 of healthy subjects in upper and lower airway: Literature Review and Meta-analysis.
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DOI：
10.7150/ijms.53500
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发表时间：
2021
影响因子：
3.6
通讯作者：
White FA
中科院分区：
文献类型：
--
作者：
Min HJ;Kim KS;Choi GJ;Kang H;White FA
尽管高迁移率族蛋白B1（HMGB1）和热休克蛋白70（HSP70）与气道疾病相关，并被认为是有潜在价值的诊断生物标志物，但其在气道中的对照浓度尚未确定。本研究旨在通过荟萃分析评估健康受试者上下气道中这两种蛋白的浓度。
我们在MEDLINE、EMBASE和谷歌学术中检索了描述健康受试者这两种蛋白浓度的文章。使用随机效应模型对来自健康人群的数据进行合并，并开展亚组分析和敏感性分析以确定研究间的异质性。我们分析了22项涉及485名受试者的研究。
健康受试者的高迁移率族蛋白B1浓度范围为“未检测到”至326.13纳克/毫升，热休克蛋白70浓度范围为0.20皮克/毫升至9240.00皮克/毫升，数值显示出显著的异质性。高迁移率族蛋白B1的亚组分析显示，下气道、上气道、儿童群体和成人的浓度分别为13.63纳克/毫升（95%置信区间12.13 - 15.14）、100.31纳克/毫升（95%置信区间 - 31.28 - 231.91）、9.54纳克/毫升（95%置信区间8.91 - 10.17）和65.82纳克/毫升（95%置信区间55.51 - 76.14），而热休克蛋白70在下气道的浓度为20.58皮克/毫升（95%置信区间7.87 - 33.29），在上气道为9240.00 ±11820皮克/毫升。尽管这些蛋白在健康受试者上下气道中的浓度有所不同，但两种蛋白在上气道中的水平均高于下气道，且这些浓度因年龄和采样方法而异。
我们的研究结果支持进一步评估这些蛋白作为气道相关疾病生物标志物的价值。
Although high-mobility group box 1 and heat-shock protein 70 are implicated in airway diseases and suggested as relevant diagnostic biomarkers, their control concentrations in the airways have not yet been determined. This study aimed to evaluate concentration of healthy subjects for both these proteins in the upper and lower airways via meta-analysis. We searched MEDLINE, EMBASE, and Google Scholar for articles describing concentration of healthy subjects for these proteins. Data from healthy populations were combined using a random-effects model, and subgroup and sensitivity analyses were performed to determine between-study heterogeneity. We analyzed 22 studies involving 485 patients. Concentration of healthy subjects of high-mobility group box 1 and heat-shock protein 70 varied from “not detected” to 326.13 ng/mL and from 0.20 pg/mL to 9240.00 pg/mL, respectively, with the values showing significant heterogeneity. Subgroup analysis for high-mobility group box 1 revealed 13.63 ng/mL (95% CI 12.13-15.14), 100.31 ng/mL (95% CI -31.28-231.91), 9.54 ng/mL (95% CI 8.91-10.17), and 65.82 ng/mL (95% CI 55.51-76.14) for the lower airway, upper airway, pediatric populations, and adults, respectively, whereas that for heat-shock protein 70 revealed 20.58 pg/mL (95% CI 7.87-33.29) for the lower airway and 9240.00 ±11820 pg/mL for the upper airway. Although concentrations of healthy subjects of these proteins varied in the upper and lower airways, the levels of both these proteins were higher in the upper airway than in the lower airway, and these concentrations differed according to the age and sampling procedure. Our findings support the further evaluation of these proteins as biomarkers for airway-related diseases.
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影响因子：
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作者：
Hozo SP;Djulbegovic B;Hozo I
通讯作者：
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影响因子：
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影响因子：
3.8
作者：
Hou Changchun;Zhao Haijin;Zou Fei
通讯作者：
Zou Fei
DOI：
10.1165/rcmb.2007-0330oc
发表时间：
2008-10-01
影响因子：
6.4
作者：
Hamada, Naoki;Maeyama, Takashige;Nakanishi, Yoichi
通讯作者：
Nakanishi, Yoichi