Immunologic Memory in Pregnancy: Focusing on Memory Regulatory T Cells.
Immunologic Memory in Pregnancy: Focusing on Memory Regulatory T Cells.
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妊娠期免疫记忆：关注记忆调节 T 细胞
DOI：
10.7150/ijbs.70629
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发表时间：
2022
影响因子：
9.2
通讯作者：
Liao AH
中科院分区：
文献类型：
--
作者：
Zhang YJ;Shen L;Zhang T;Muyayalo KP;Luo J;Mor G;Liao AH
成功怀孕需要母体免疫系统能够耐受异体胎儿。子痫前期和其他与胎儿耐受性受损相关的并发症在第二次妊娠中的发生率低于第一次妊娠。同时，与前一次妊娠的正常孕妇相比，前一次妊娠出现妊娠并发症的患者再次妊娠时患此病的风险也有所增加。这种差异可能与怀孕的免疫记忆有关。调节性T细胞（Tregs）是免疫抑制CD4+ T细胞，在维持免疫耐受中起主要作用。此外，treg还具有免疫记忆特性，包括胎儿或父亲特异性记忆treg和表达记忆细胞的treg，形成针对胎儿抗原的免疫调节性记忆。在这篇综述中，我们概述了妊娠期记忆Tregs的特征，以及人类妊娠期记忆Tregs存在的证据，以及小鼠模型。我们还讨论了记忆Tregs的诱导、维持和作用机制。此外，我们还描述了它们在第一胎、第二胎、产后和病理妊娠期间的变化，以期为妊娠相关疾病的诊断和治疗提供新的靶点。
A successful pregnancy requires the maternal immune system to tolerate an allogeneic fetus. The incidence of preeclampsia and other complications related to impaired fetal tolerance is lower during the second pregnancy than during the first pregnancy. At the same time, compared with normal pregnant women in the previous pregnancy, patients with pregnancy complications in the previous pregnancy also have an increased risk of the disease when they become pregnant again. This difference may be related to the immunological memory of pregnancy. Regulatory T cells (Tregs) are immunosuppressive CD4+ T cells that play a predominant role in maintaining immune tolerance. In addition, Tregs possess immunological memory properties, including fetal or paternal-specific memory Tregs and Tregs expressing memory cell makers, forming an immunoregulatory memory against fetal antigens. In this review, we provide an overview of the characteristics of memory Tregs in pregnancy, evidence regarding the existence of memory Tregs in human pregnancy, as well as in mouse models. We also discuss the mechanism of memory Tregs induction, maintenance, and action. In addition, we described their changes during the first pregnancy, second pregnancy, postpartum, and pathological pregnancy in order to provide new targets for the diagnosis and treatment of pregnancy related diseases.
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DOI：
10.1146/annurev-pathmechdis-012418-012743
发表时间：
2019-01-24
期刊：
Annual review of pathology
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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DOI：
10.1111/j.1600-0897.2011.01046.x
发表时间：
2011-07-01
影响因子：
3.6
作者：
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通讯作者：
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影响因子：
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