The effect of an intronic polymorphism on alcohol dehydrogenase expression in Drosophila melanogaster.
The effect of an intronic polymorphism on alcohol dehydrogenase expression in Drosophila melanogaster.
复制标题
内含子多态性对果蝇乙醇脱氢酶表达的影响。
作者：
C. Laurie;L. F. Stam
有证据表明，自然选择控制果蝇乙醇脱氢酶（Adh）基因座等位酶多态性的频率。然而，由于在Adh区域的序列多态性之间的关联，目前尚不清楚选择是否直接（或单独）作用于等位酶位点。这个问题已经接近通过使用体外诱变来区分个体多态性对Adh表达的影响。这项研究表明，在第一个Adh内含子（delta 1）的多态性对ADH蛋白的水平有显着的影响。和等位酶一样，delta 1在频率上也显示出地理渐变，表明它也可能是自然选择的目标。这些结果表明，多位点选择模型可能需要了解个别位点的进化动力学。
Several lines of evidence indicate that natural selection controls the frequencies of an allozyme polymorphism at the alcohol dehydrogenase (Adh) locus in Drosophila melanogaster. However, because of associations among sequence polymorphisms in the Adh region, it is not clear whether selection acts directly (or solely) on the allozymic site. This problem has been approached by using in vitro mutagenesis to distinguish among the effects on Adh expression of individual polymorphisms. This study shows that a polymorphism within the first Adh intron (delta 1) has a significant effect on the level of ADH protein. Like the allozyme, delta 1 shows a geographic cline in frequency, indicating that it may also be a target of natural selection. These results suggest that multisite selection models may be required to understand the evolutionary dynamics of individual loci.
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DOI：
10.1073/pnas.83.10.3562
发表时间：
1986-05-01
影响因子：
11.1
作者：
KREITMAN, M;AGUADE, M
通讯作者：
AGUADE, M
影响因子：
3.3
作者：
M. Kreitman;R. Hudson
通讯作者：
M. Kreitman;R. Hudson
影响因子：
3.5
作者：
David Munroe;Allan Jacobson
通讯作者：
David Munroe;Allan Jacobson
使用 P 元件介导的转化来鉴定影响果蝇 Adh 表达的自然发生变异的分子基础。
影响因子：
3.3
作者：
Laurie-Ahlberg,CC;Stam,LF
通讯作者：
Stam,LF