Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.
Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.
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DOI：
10.1155/2014/753524
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发表时间：
2014
影响因子：
2.8
通讯作者：
Florio T
中科院分区：
文献类型：
--
作者：
Barbieri F;Thellung S;Würth R;Gatto F;Corsaro A;Villa V;Nizzari M;Albertelli M;Ferone D;Florio T
趋化因子是炎症、感染和癌症等生理和病理条件下免疫监视的趋化调节剂。几种趋化因子和同源受体在中枢神经系统中组成型表达，不仅在神经胶质细胞和内皮细胞中，而且在神经元中表达，控制发育过程中的神经发生、神经突生长和轴突引导。特别是趋化因子CXCL12及其受体CXCR4和CXCR7形成一个功能网络，控制不同脑区的可塑性，影响神经传递、神经调节和细胞迁移，而该趋化因子轴的失调与多种神经退行性、神经炎症和恶性疾病有关。 CXCR4 主要介导增殖信号的转导，而 CXCR7 似乎主要负责清除 CXCL12。重要的是，CXCL12与其受体相互作用产生的多种细胞内信号影响下丘脑对神经内分泌功能的调节，尽管也有报道通过自分泌/旁分泌机制直接调节垂体功能。 CXCL12 和 CXCR4 在垂体腺瘤中持续过度表达，它们的信号传导可诱导细胞存活和增殖以及激素分泌过多。在这篇综述中，我们重点关注免疫相关细胞因子和趋化因子的生理和病理功能，主要关注CXCL12/CXCR4-7轴，及其在垂体肿瘤发生中的作用。因此，我们讨论了 CXCR4 作为垂体腺瘤新药理学方法的潜在靶点。
Chemokines are chemotactic regulators of immune surveillance in physiological and pathological conditions such as inflammation, infection, and cancer. Several chemokines and cognate receptors are constitutively expressed in the central nervous system, not only in glial and endothelial cells but also in neurons, controlling neurogenesis, neurite outgrowth, and axonal guidance during development. In particular, the chemokine CXCL12 and its receptors, CXCR4 and CXCR7, form a functional network that controls plasticity in different brain areas, influencing neurotransmission, neuromodulation, and cell migration, and the dysregulation of this chemokinergic axis is involved in several neurodegenerative, neuroinflammatory, and malignant diseases. CXCR4 primarily mediates the transduction of proliferative signals, while CXCR7 seems to be mainly responsible for scavenging CXCL12. Importantly, the multiple intracellular signalling generated by CXCL12 interaction with its receptors influences hypothalamic modulation of neuroendocrine functions, although a direct modulation of pituitary functioning via autocrine/paracrine mechanisms was also reported. Both CXCL12 and CXCR4 are constitutively overexpressed in pituitary adenomas and their signalling induces cell survival and proliferation, as well as hormonal hypersecretion. In this review we focus on the physiological and pathological functions of immune-related cyto- and chemokines, mainly focusing on the CXCL12/CXCR4-7 axis, and their role in pituitary tumorigenesis. Accordingly, we discuss the potential targeting of CXCR4 as novel pharmacological approach for pituitary adenomas.
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趋化因子网络在卵巢癌发展和发展中的作用：潜在的新型药理靶标。
影响因子：
--
作者：
Barbieri, Federica;Bajetto, Adriana;Florio, Tullio
通讯作者：
Florio, Tullio
影响因子：
11.5
作者：
Barbieri, Federica;Bajetto, Adriana;Florio, Tullio
通讯作者：
Florio, Tullio
影响因子：
4.7
作者：
Bajetto, A;Bonavia, R;Schettini, G
通讯作者：
Schettini, G
DOI：
10.1155/2013/926295
发表时间：
2013
期刊：
International journal of peptides
影响因子：
--
作者：
Barbieri F;Bajetto A;Pattarozzi A;Gatti M;Würth R;Thellung S;Corsaro A;Villa V;Nizzari M;Florio T
通讯作者：
Florio T
影响因子：
5.3
作者：
Belmadani, A;Tran, PB;Miller, RJ
通讯作者：
Miller, RJ