Multifunctions of CRIF1 in cancers and mitochondrial dysfunction.
Multifunctions of CRIF1 in cancers and mitochondrial dysfunction.
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DOI：
10.3389/fonc.2022.1009948
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发表时间：
2022
影响因子：
4.7
通讯作者：
Li, Zhongjun
中科院分区：
文献类型：
--
作者：
Jiang, Yangzhou;Xiang, Yang;Lin, Chuanchuan;Zhang, Weiwei;Yang, Zhenxing;Xiang, Lixin;Xiao, Yanni;Chen, Li;Ran, Qian;Li, Zhongjun
关键词：
维持增殖信号传导和使复制永生成为可能是癌症的两个重要标志。细胞周期蛋白依赖性激酶（cyclin-dependent kinase，CDK）与细胞周期蛋白（cyclin）的复合体在细胞周期的转化中起决定性作用，在肿瘤的发生和发展中也起着关键作用。CRIF 1是一种多功能因子，在细胞周期、细胞增殖、能量代谢等一系列细胞生物学过程中发挥着重要作用。CRIF 1最为人所知的是作为细胞周期的负调控因子，因为它直接结合Gadd 45家族蛋白或CDK 2。此外，CRIF 1还作为Nur 77和STAT 3等几种转录因子的调节因子，并部分决定癌细胞的增殖。许多研究表明CRIF 1的表达在癌症中显著改变，并可能被视为肿瘤抑制因子。这表明靶向CRIF 1将提高癌症治疗的选择性和敏感性。CRIF 1可能是线粒体中不可缺少的一部分，参与OXPHOS能力的调节。此外，CRIF 1被认为是线粒体功能障碍疾病的潜在机制的新靶标。总之，本文将总结CRIF 1在癌症和乳腺癌相关疾病中的最新研究，为靶向治疗提供新的思路，并提供更全面的整体观点。
Sustaining proliferative signaling and enabling replicative immortality are two important hallmarks of cancer. The complex of cyclin-dependent kinase (CDK) and its cyclin plays a decisive role in the transformation of the cell cycle and is also critical in the initiation and progression of cancer. CRIF1, a multifunctional factor, plays a pivotal role in a series of cell biological progresses such as cell cycle, cell proliferation, and energy metabolism. CRIF1 is best known as a negative regulator of the cell cycle, on account of directly binding to Gadd45 family proteins or CDK2. In addition, CRIF1 acts as a regulator of several transcription factors such as Nur77 and STAT3 and partly determines the proliferation of cancer cells. Many studies showed that the expression of CRIF1 is significantly altered in cancers and potentially regarded as a tumor suppressor. This suggests that targeting CRIF1 would enhance the selectivity and sensitivity of cancer treatment. Moreover, CRIF1 might be an indispensable part of mitoribosome and is involved in the regulation of OXPHOS capacity. Further, CRIF1 is thought to be a novel target for the underlying mechanism of diseases with mitochondrial dysfunctions. In summary, this review would conclude the latest aspects of studies about CRIF1 in cancers and mitochondria-related diseases, shed new light on targeted therapy, and provide a more comprehensive holistic view.
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DOI：
10.3390/antiox10111645
发表时间：
2021-10-20
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Lee I;Piao S;Kim S;Nagar H;Choi SJ;Jeon BH;Oh SH;Irani K;Kim CS
通讯作者：
Kim CS
影响因子：
9.7
作者：
Jamroze A;Chatta G;Tang DG
通讯作者：
Tang DG
影响因子：
14.5
作者：
Deng P;Haynes CM
通讯作者：
Haynes CM
雷公藤红素诱导的 Nur77 与 TRAF2 相互作用通过促进线粒体泛素化和自噬减轻炎症
影响因子：
16
作者：
Hu M;Luo Q;Alitongbieke G;Chong S;Xu C;Xie L;Chen X;Zhang D;Zhou Y;Wang Z;Ye X;Cai L;Zhang F;Chen H;Jiang F;Fang H;Yang S;Liu J;Diaz-Meco MT;Su Y;Zhou H;Moscat J;Lin X;Zhang XK
通讯作者：
Zhang XK
影响因子：
4.8
作者：
Chung, HK;Yi, YW;Shong, MH
通讯作者：
Shong, MH