A Comparison of Five Brief Screening Tools for HIV-Associated Neurocognitive Disorders in the USA and South Africa.
A Comparison of Five Brief Screening Tools for HIV-Associated Neurocognitive Disorders in the USA and South Africa.
复制标题
美国和南非艾滋病毒相关神经认知障碍五种简要筛查工具的比较。
DOI：
10.1007/s10461-016-1316-y
复制
发表时间：
2016-08
影响因子：
4.4
通讯作者：
Sacktor NC
中科院分区：
文献类型：
--
作者：
Joska JA;Witten J;Thomas KG;Robertson C;Casson-Crook M;Roosa H;Creighton J;Lyons J;McArthur J;Sacktor NC
筛查HIV相关的神经认知障碍（HAND）对改善临床结局非常重要。我们比较了简易精神状态检查、国际艾滋病痴呆量表（IHDS）、蒙特利尔认知评估、Simioni症状问卷和认知评估工具快速版（CAT-rapid）与金标准神经心理学电池的诊断敏感性和特异性。招募了来自南非开普敦和美国巴尔的摩的抗逆转录病毒经验丰富的参与者。使用2 × 2列联表和ROC分析确定了5种工具以及IHDS和CAT-rapid联合使用的敏感性和特异性。超过三分之一（65165）有症状性手。在检测HIV-D时，CAT-Rapid具有良好的灵敏度（94%）和弱特异性（52%）（临界点≤10），而IHDS显示出中等灵敏度（68%）和良好的特异性（86%）（临界点≤10）。IHDS和CAT-rapid联合检测在≤16分的临界值（20分中的89和82%）下显示出对HIV-D的极佳敏感性和特异性。没有工具足以筛查任何手。IHDS和CAT快速工具的组合似乎是一个很好的HIV-D筛查工具，但在筛查任何HAND时仅相当敏感且特异性差。筛查轻度HAND仍然是一个临床挑战。
Screening for HIV-associated neurocognitive disorders (HAND) is important to improve clinical outcomes. We compared the diagnostic sensitivity and specificity of the mini-mental state examination, International HIV dementia scale (IHDS), Montreal cognitive assessment, Simioni symptom questionnaire and cognitive assessment tool-rapid version (CAT-rapid) to a gold standard neuropsychological battery. Antiretroviral-experienced participants from Cape Town, South Africa, and Baltimore, USA, were recruited. The sensitivity and specificity of the five tools, as well as those of the combined IHDS and CAT-rapid, were established using 2 × 2 contingency tables and ROC analysis. More than a third (65165) had symptomatic HAND. In detecting HIV-D, the CAT-Rapid had good sensitivity (94 %) and weak specificity (52 %) (cut-point ≤10), while the IHDS showed fair sensitivity (68 %) and good specificity (86 %) (cut-point ≤10). The combined IHDS and CAT-rapid showed excellent sensitivity and specificity for HIV-D at a cut-off score of ≤16 (out of 20; 89 and 82 %). No tool was adequate in screening for any HAND. The combination IHDS and CAT-rapid tool appears to be a good screener for HIV-D but is only fairly sensitive and poorly specific in screening for any HAND. Screening for milder forms of HAND continues to be a clinical challenge.
登录
查看更多内容
影响因子：
3.2
作者：
de Almeida, Sergio Monteiro;Ribeiro, Clea Elisa;de Pereira, Ana Paula;Badiee, Jayraan;Cherner, Mariana;Smith, Davey;Maich, Ingrid;Raboni, Sonia Mara;Rotta, Indianara;Barbosa, Francisco Jaime;Heaton, Robert K.;Umlauf, Anya;Ellis, Ronald J.
通讯作者：
Ellis, Ronald J.
影响因子：
3
作者：
Ku NS;Lee Y;Ahn JY;Song JE;Kim MH;Kim SB;Jeong SJ;Hong KW;Kim E;Han SH;Song JY;Cheong HJ;Song YG;Kim WJ;Kim JM;Smith DM;Choi JY
通讯作者：
Choi JY
影响因子：
9.9
作者：
Grant, Igor;Franklin, Donald R., Jr.;Heaton, Robert K.
通讯作者：
Heaton, Robert K.
影响因子：
3.2
作者：
Heaton RK;Cysique LA;Jin H;Shi C;Yu X;Letendre S;Franklin DR Jr;Ake C;Vigil O;Atkinson JH;Marcotte TD;Grant I;Wu Z;HNRC group
通讯作者：
HNRC group
影响因子：
11.8
作者：
Antinori, Andrea;Arendt, Gabriele;Munoz-Moreno, Jose A.
通讯作者：
Munoz-Moreno, Jose A.