Association Between Acoustic Features and Neuropsychological Test Performance in the Framingham Heart Study: Observational Study.
Association Between Acoustic Features and Neuropsychological Test Performance in the Framingham Heart Study: Observational Study.
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DOI：
10.2196/42886
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发表时间：
2022-12-22
影响因子：
7.4
通讯作者：
Lin, Honghuang
中科院分区：
文献类型：
--
作者：
Ding, Huitong;Mandapati, Amiya;Karjadi, Cody;Ang, Ting Fang Alvin;Lu, Sophia;Miao, Xiao;Glass, James;Au, Rhoda;Lin, Honghuang
人类声音越来越被认为是检测认知障碍的有效指标。然而，声学特征与特定认知功能和轻度认知障碍 (MCI) 的关联尚未在大量社区人群中进行评估。本研究旨在调查多个认知领域的声学特征与神经心理学 (NP) 测试之间的关联，并评估声学综合评分对 MCI 分类的附加预测能力。这项研究包括来自弗雷明汉心脏研究的没有痴呆症的参与者，这是一个基于社区的大型队列，对痴呆症事件进行纵向监测。对于每个参与者，65 个低级声学描述符来自 NP 测试管理的录音。使用针对年龄、性别和教育程度进行调整的线性混合效应模型评估个体声学描述符和 18 项 NP 测试之间的关联。然后通过结合与 NP 测试显着相关的声学特征来构建声学综合分数。还评估了声学综合评分对流行和偶发 MCI 的附加预测能力。该研究包括 4950 名参与者（年龄：平均 62 岁，SD 14 岁；4336/7874，55.07% 女性）的 7874 份录音，其中 453 人被诊断患有 MCI。总而言之，在调整多次测试后，8 项 NP 测试与超过 15 个声学特征相关。此外，其中 4 个声学综合评分与流行的 MCI 显着相关，7 个与偶发 MCI 相关。声学综合得分可以将 MCI 预测的基线模型曲线下面积从 0.712 增加到 0.755。多种声学特征与 NP 测试表现和 MCI 显着相关，这有可能用作早期认知障碍监测的数字生物标志物。
Human voice has increasingly been recognized as an effective indicator for the detection of cognitive disorders. However, the association of acoustic features with specific cognitive functions and mild cognitive impairment (MCI) has yet to be evaluated in a large community-based population. This study aimed to investigate the association between acoustic features and neuropsychological (NP) tests across multiple cognitive domains and evaluate the added predictive power of acoustic composite scores for the classification of MCI. This study included participants without dementia from the Framingham Heart Study, a large community-based cohort with longitudinal surveillance for incident dementia. For each participant, 65 low-level acoustic descriptors were derived from voice recordings of NP test administration. The associations between individual acoustic descriptors and 18 NP tests were assessed with linear mixed-effect models adjusted for age, sex, and education. Acoustic composite scores were then built by combining acoustic features significantly associated with NP tests. The added prediction power of acoustic composite scores for prevalent and incident MCI was also evaluated. The study included 7874 voice recordings from 4950 participants (age: mean 62, SD 14 years; 4336/7874, 55.07% women), of whom 453 were diagnosed with MCI. In all, 8 NP tests were associated with more than 15 acoustic features after adjusting for multiple testing. Additionally, 4 of the acoustic composite scores were significantly associated with prevalent MCI and 7 were associated with incident MCI. The acoustic composite scores can increase the area under the curve of the baseline model for MCI prediction from 0.712 to 0.755. Multiple acoustic features are significantly associated with NP test performance and MCI, which can potentially be used as digital biomarkers for early cognitive impairment monitoring.
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影响因子：
--
作者：
Lin H;Karjadi C;Ang TFA;Prajakta J;McManus C;Alhanai TW;Glass J;Au R
通讯作者：
Au R
DOI：
10.1076/1380-3395(200008)22:4;1-0;ft518
发表时间：
2000-01-01
影响因子：
2.2
作者：
Arbuthnott, K;Frank, J
通讯作者：
Frank, J
影响因子：
9.9
作者：
Deramecourt, V.;Lebert, F.;Pasquier, F.
通讯作者：
Pasquier, F.
DOI：
10.1109/89.326616
发表时间：
1994-10-01
期刊：
IEEE TRANSACTIONS ON SPEECH AND AUDIO PROCESSING
影响因子：
--
作者：
Hermansky, Hynek;Morgan, Nelson
通讯作者：
Morgan, Nelson
DOI：
10.1016/j.jalz.2013.01.013
发表时间：
2014-01
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Henriksen K;O'Bryant SE;Hampel H;Trojanowski JQ;Montine TJ;Jeromin A;Blennow K;Lönneborg A;Wyss-Coray T;Soares H;Bazenet C;Sjögren M;Hu W;Lovestone S;Karsdal MA;Weiner MW;Blood-Based Biomarker Interest Group
通讯作者：
Blood-Based Biomarker Interest Group