Modulation of cytokine and cytokine receptor/antagonist by treatment with doxycycline and tetracycline in patients with dengue fever.
Modulation of cytokine and cytokine receptor/antagonist by treatment with doxycycline and tetracycline in patients with dengue fever.
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DOI：
10.1155/2011/370872
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发表时间：
2011
影响因子：
--
通讯作者：
Fredeking TM
中科院分区：
文献类型：
--
作者：
Castro JE;Vado-Solis I;Perez-Osorio C;Fredeking TM
登革病毒感染可导致登革热（DF）或登革出血热（DHF）。疾病的严重程度与各种细胞因子水平的增加有关。在这项研究中，我们评估了多西环素和四环素调节DF或DHF患者血清IL-6、IL-1B和TNF以及细胞因子受体/受体拮抗剂TNF-R1和IL-1 RA水平的有效性。住院患者随机接受标准支持治疗或支持治疗联合强力霉素或四环素治疗。血清细胞因子和细胞因子受体/拮抗剂水平测定治疗开始时和3和7天后。细胞因子和细胞因子受体/拮抗剂水平在第0天显著升高。在整个研究期间，未经治疗的患者中IL-6、IL-1β和TNF保持在或高于第0天水平。四环素或强力霉素治疗导致细胞因子水平显著下降。类似地，IL-1 RA和TNF-R1血清浓度在基线时升高，并且在未治疗的患者中显示出中度升高。两种药物均导致患者第3天IL-1 Ra水平显著升高。相反，治疗不影响TNF-R1的类似结果。然而，与对照组相比，在组内分析时观察到治疗后显著升高。进一步的分析表明，多西环素在调节细胞因子和细胞因子受体/拮抗剂水平方面比四环素显著更有效。
Dengue virus infection can lead to dengue fever (DF) or dengue hemorrhagic fever (DHF). Disease severity has been linked to an increase in various cytokine levels. In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF. Hospitalized patients were randomized to receive standard supportive care or supportive care combined with doxycycline or tetracycline therapy. Serum cytokine and cytokine receptor/antagonist levels were determined at the onset of therapy and after 3 and 7 days. Cytokine and cytokine receptor/antagonist levels were substantially elevated at day 0. IL-6, IL-1β, and TNF remained at or above day 0 levels throughout the study period in untreated patients. Treatment with tetracycline or doxycycline resulted in a significant decline in cytokine levels. Similarly, IL-1RA and TNF-R1 serum concentrations were elevated at baseline and showed a moderate increase among untreated patients. Both drugs resulted in a significant rise in IL-1Ra levels by day 3 in patients. In contrast, treatment did not affect a similar result for TNF-R1. When compared to the control group, however, a significant rise post-treatment was seen upon intragroup analysis. Further analysis demonstrated that doxycycline was significantly more effective at modulating cytokine and cytokine receptor/antagonist levels than tetracycline.
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影响因子：
6.4
作者：
Bethell, DB;Flobbe, K;Kwiatkowski, D
通讯作者：
Kwiatkowski, D
影响因子：
6.4
作者：
Green, S;Vaughn, DW;Ennis, FA
通讯作者：
Ennis, FA
DOI：
10.1177/1352458506070319
发表时间：
2007-05-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Zabad, R. K.;Metz, L. M.;Yong, V. W.
通讯作者：
Yong, V. W.
DOI：
10.1073/pnas.0711942105
发表时间：
2008-06-10
影响因子：
11.1
作者：
Zheng, Bo-Jian;Chan, Kwok-Wah;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
3.1
作者：
LEHMANN, AK;HALSTENSEN, A;WAAGE, A
通讯作者：
WAAGE, A