Whole genome sequences of 2 octogenarians with sustained cognitive abilities.
Whole genome sequences of 2 octogenarians with sustained cognitive abilities.
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DOI：
10.1016/j.neurobiolaging.2014.11.003
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发表时间：
2015-03
影响因子：
4.2
通讯作者：
Oksenberg JR
中科院分区：
文献类型：
--
作者：
Nickles D;Madireddy L;Patel N;Isobe N;Miller BL;Baranzini SE;Kramer JH;Oksenberg JR
虽然已经确定了许多影响衰老和死亡率的遗传变异，例如APOE ε4，但影响认知衰老的遗传成分尚未完全确定。更好地了解衰老的遗传学将有助于理解潜在的生物学过程。在这里，我们描述了两个女性的基因组序列。我们提供了这两个基因组变异的共同点。我们还描述了与先前报道的两个超级百岁老人（年龄≥ 110岁的个体）的基因组的重叠。我们评估了老年人和非老年对照组基因组的遗传疾病倾向，没有发现支持长寿健康个体可能比普通人群表现出更大的遗传适应性的假设。此外，没有证据表明先前描述的促进长寿的变异在这两种长寿动物中积累。这些发现表明，目前定义的遗传适应性并不是延长寿命的唯一因素。我们确定了一些健康认知老化的候选基因位点，等待在更大的研究中确认。
Although numerous genetic variants affecting aging and mortality have been identified, e.g. APOE ε4, the genetic component influencing cognitive aging has not been fully defined yet. A better knowledge of the genetics of aging will prove helpful in understanding the underlying biological processes. Here, we describe the whole genome sequences of two female octogenarians. We provide the repertoire of genomic variants that the two octogenarians have in common. We also describe the overlap with the previously reported genomes of two supercentenarians - individuals aged ≥ 110 years. We assessed the genetic disease propensities of the octogenarians and non-aged control genomes and could not find support for the hypothesis that long-lived healthy individuals might exhibit greater genetic fitness than the general population. Furthermore, there is no evidence for an accumulation of previously described variants promoting longevity in the two octogenarians. These findings suggest that genetic fitness, as currently defined, is not the sole factor enabling an increased lifespan. We identified a number of healthy-cognitive-aging candidate genetic loci awaiting confirmation in larger studies.
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影响因子：
3.7
作者：
Sebastiani P;Riva A;Montano M;Pham P;Torkamani A;Scherba E;Benson G;Milton JN;Baldwin CT;Andersen S;Schork NJ;Steinberg MH;Perls TT
通讯作者：
Perls TT
影响因子：
7
作者：
Boyle AP;Hong EL;Hariharan M;Cheng Y;Schaub MA;Kasowski M;Karczewski KJ;Park J;Hitz BC;Weng S;Cherry JM;Snyder M
通讯作者：
Snyder M
DOI：
10.1093/gerona/glr223
发表时间：
2012-04-01
影响因子：
5.1
作者：
Andersen, Stacy L.;Sebastiani, Paola;Perls, Thomas T.
通讯作者：
Perls, Thomas T.
影响因子：
2.1
作者：
Hu, Hao;Huff, Chad D.;Moore, Barry;Flygare, Steven;Reese, Martin G.;Yandell, Mark
通讯作者：
Yandell, Mark
影响因子：
14.9
作者：
Landrum MJ;Lee JM;Riley GR;Jang W;Rubinstein WS;Church DM;Maglott DR
通讯作者：
Maglott DR