Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences.
Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences.
复制标题
DOI：
10.1007/s00213-010-2118-y
复制
发表时间：
2011-03
影响因子：
3.4
通讯作者：
Champagne, Danielle L.
中科院分区：
文献类型：
--
作者：
Claessens, Sanne E. F.;Daskalakis, Nikolaos P.;van der Veen, Rixt;Oitzl, Melly S.;de Kloet, E. Ronald;Champagne, Danielle L.
人类流行病学和动物研究令人信服地表明，早期生活经历对晚年生活中压力反应的个体差异的发展具有长期影响。基因和环境之间的相互作用是这种现象的基础。我们提供了一个概述的研究调查的影响，早期生活经验的个体差异的发展，在成年期的神经内分泌应激反应和地址（1）环境对后来的压力表型的影响，（2）遗传因素的作用，在调节环境的结果，和（3）非共享的环境经验的作用，在基因×环境相互作用的结果。我们提出了原始的研究结果，我们调查了非共享经验的影响，在接受孕产妇护理的个体差异，在以后的生活中大鼠的压力表型的发展。生命早期的环境影响对后来的应激表型产生了强大的影响，但它们并不总是导致疾病的表达。异源性反应是由特定的遗传因素在调节环境影响中的作用来解释的。非共享经验在人类基因×环境相互作用的结果中很重要。我们发现，非共享经验获得通过内窝的变化，在产妇护理大鼠预测的压力表型的后代。早期经验的结果是不确定的，取决于几个环境和遗传因素以复杂的方式相互作用，以支持压力适应。早期和晚期生活环境之间的“匹配”和“不匹配”程度分别预测了对与压力有关的疾病的复原力和脆弱性。本文的在线版本（doi：10.1007/s 00213 -010-2118-y）包含补充材料，可供授权用户使用。
Human epidemiology and animal studies have convincingly shown the long-lasting impact of early life experiences on the development of individual differences in stress responsiveness in later life. The interplay between genes and environment underlies this phenomenon. We provide an overview of studies investigating the impact of early life experiences on the development of individual differences in neuroendocrine stress responsiveness in adulthood and address (1) impact of environment on later stress phenotypes, (2) role of genetic factors in modulating the outcome of environment, and (3) role of nonshared environmental experience in the outcome of gene × environment interplays. We present original findings where we investigated the influence of nonshared experiences in terms of individual differences in maternal care received, on the development of stress phenotype in later life in rats. Environmental influences in early life exert powerful effects on later stress phenotypes, but they do not always lead to expression of diseases. Heterogeneity in response is explained by the role of particular genetic factors in modulating the influence of environment. Nonshared experiences are important in the outcome of gene × environment interplays in humans. We show that nonshared experiences acquired through within-litter variation in maternal care in rats predict the stress phenotype of the offspring. The outcome of early experience is not deterministic and depends on several environmental and genetic factors interacting in an intricate manner to support stress adaptation. The degree of “match” and “mismatch” between early and later life environments predicts resilience and vulnerability to stress-related diseases, respectively. The online version of this article (doi:10.1007/s00213-010-2118-y) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
3
作者：
Champagne, Danielle L.;de Kloet, E. Ronald;Joels, Marian
通讯作者：
Joels, Marian
DOI：
10.1111/j.1469-7610.2007.01818.x
发表时间：
2008-01-01
影响因子：
7.6
作者：
Albers, Esther M.;Riksen-Walraven, J. Marianne;de Weerth, Carolina
通讯作者：
de Weerth, Carolina
DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
2.2
作者：
DEVITERNE, D;DESOR, D
通讯作者：
DESOR, D
影响因子：
56.9
作者：
Caspi, A;McClay, J;Poulton, R
通讯作者：
Poulton, R